摘要
目的研究FAS-1377基因多态与胃癌TNM分期的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法,检测120例胃癌患者的FAS-1377基因多态性,用Pearsonχ2检验法分析其基因多态性与胃癌TNM分期的关系。结果 FAS-1377基因多态频率分布:纯合野生型GG为7.4%(7/95)、杂合型GA为61.1%(58/95)、纯合突变型AA为31.5%(30/95)。胃癌患者FAS-1377基因型与TNM分期无统计学意义(P=0.274)。结论 FAS-1377基因多态与青海地区胃癌患者TNM分期无相关性。
Objective To investigate the correlation between FAS polymorphisms and TNM staging of gastric cancer. Methods The polymorphisms of FAS were detected by polymerase chain reaction - restriction fragment length polymorphisms assay （PCR -RFLP） in 120 gastric cancer patients ,Pearson X2 was applied to assess the association between the polymorphisms of FAS and TNM staging of gastric cancer. Results The frequency of FAS - 1377 gene polymorphism is that homozygous wild -type GG is 7.4 percent （7/95）, heterozygous GA is 61.1 percent（58/95） and homozygous mutant AA is 31.5 percent（30/95）. FAS- 1377 gene polymorphism of gastric cancer patients was not associated with clinical stage, （P = 0. 274）. Conclusions FAS - 1377 may not be associated with TNM staging of gastric cancer.
出处
《青海医学院学报》
CAS
2010年第4期239-241,共3页
Journal of Qinghai Medical College
基金
青海大学中青年科研基金项目(2008-QY-10)资助
关键词
胃癌
凋亡基因
基因多态性
分期
Gastric cancer Apoptotic gene Gene polymorphisms Stage
