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全基因组关联研究现状 被引量：28

Current status of genome-wide association study
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摘要 在过去的5年中,全基因组关联研究(Genome-wide association study,GWAS)方法已被证明是研究复杂疾病和性状遗传易感变异的一种有效手段。目前,各国科学家在多种复杂疾病和性状中开展了大量的GWAS,对肿瘤、糖尿病、心脏病、神经精神疾病、自身免疫及免疫相关疾病等复杂疾病以及一些常见性状(如身高、体重、血脂、色素等)的遗传易感基因研究取得了重大成果。截止到2010年9月11日,运用GWAS开展了对近200种复杂疾病/性状的研究,发现了3000多个疾病相关的遗传变异。文章就GWAS的发展及其在复杂疾病/性状中的应用做一综述。 In past five years,genome-wide association study（GWAS） has proven to be a powerful and efficient study design in identifying genetic variants associated with complex diseases and traits.Many studies have been performed to explore the genetic basis of various complex diseases and traits.Genetic breakthroughs have been achieved in complex diseases and traits,such as oncology,diabetes,cardiology,psychiatric disorders,autoimmune and immune related diseases,height,weight,blood lipid,and pigmentation.Up to September 11th 2010,nearly 200 complex diseases and traits have been investigated by this approach,and more than 3000 diseases and/or traits related variants have been identified.In this review,we present an overview of GWAS in complex diseases and traits.
作者 韩建文 张学军
机构地区 安徽医科大学皮肤病学研究所
出处 《遗传》 CAS CSCD 北大核心 2011年第1期25-35,共11页 Hereditas（Beijing)
基金 国家"863"计划项目(编号:2007AA02Z161)资助
关键词 全基因组关联研究 复杂疾病 性状 易感基因 genome-wide association complex diseases traits susceptibility gene
分类号 Q75 [生物学—分子生物学]
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参考文献25

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同被引文献382

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二级引证文献133

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2011年 第1期

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