摘要
目的检测转化生长因子β1(TGF-β1)在睾丸肿瘤组织中的表达,并探讨其临床意义。方法采用免疫组织化学法检測60例睾丸肿瘤组织和10例正常睾丸组织中TGF-β1蛋白的表达情况。结果睾丸肿瘤组织中TGF-β1蛋白的阳性表达率为85.0%,而正常睾丸组织中为10.0%,二者有明显的统计学差异(P<0.05);睾丸肿瘤组织高分化组的TGF-β1阳性表达率明显低于低分化组(P<0.05);睾丸肿瘤组织的临床分期越高,TGF-β1的阳性表达率越高(P<0.05);有淋巴结转移组的TGF-β1的阳性表达率明显高于无淋巴结转移组(P<0.05)。表明TGF-β1高表达与睾丸肿瘤的病理分级、临床分期及淋巴结转移有关。结论 TGF-β1在睾丸肿瘤的生长、浸润和转移过程中起着重要作用。TGF-β1可能成为一种反映睾丸肿瘤生物侵袭性的标志物。
Objective To determine the expression of transforming growth factor-β1（TGF-β1） in testicular tumors and assess its clinical significance.Methods Immunohistochemical staining for TGF-β1 was performed using paraffin-embedded tissues from 60 cases of testicular tumors and 20 cases of normal testicular tissues.Results The positive expression rate of TGF-β1 in testicular tumors was 85.0%,while that of the normal testicular tissues group was 10.0%（P0.05）.A significant increase in TGF-β1 expression was associated with increased testicular tumor grade,increased testicular tumor stage and distant metastasis（P0.05）.Conclusion TGF-β1 plays an important role in the proliferation,invasion and metastasis of testicular tumors.TGF-β1 could be a predictive marker for the invasion ability of testicular tumors.
出处
《现代泌尿外科杂志》
CAS
2011年第1期42-44,共3页
Journal of Modern Urology
