摘要
【目的】探讨微小染色体维持蛋白5（MCM5）在宫颈鳞癌和宫颈上皮内瘤（cIN）变中的表达及其临床意义。【方法】采用免疫组化法检测MCM5在66例宫颈鳞癌及90例CIN中的表达，通过标记指数（LI）计算MCM5在宫颈病变中表达情况，并分析其与临床病理学特征之间的关系。【结果IMCM5的表达从CIN到宫颈鳞癌逐渐增高：在CINⅠ，CINⅡ，CINⅢ，宫颈鳞癌中LI中位数分别为36．45%，60．43%，79．52％，90．34％。4组间比较差异有统计学意义（P〈0．01）；在宫颈鳞癌高、中、低分化组中MCM5表达逐渐升高，差异有统计学意义（P〈0．01），而在FIGO分期、年龄、淋巴结是否转移各组中差异均无统计学意义（P〉0．05）。【结论]MCM5是一种新型的细胞增殖标志物，可以作为宫颈病变预后的参考指标，其表达水平与宫颈鳞癌分化程度有关。
[Objective] To explore the expression of minute chromosome maintenance protein 5（MCM5） in squamous cell carcinoma of the cervix and cervical intraepithelial neoplasia（CIN） and its clinical significance. [Methods]Immunohistochemistry staining method was used to detect the expression of MCM5 in 66 cases of cervical squamous cell carcinoma and 90 cases of CIN. The relationship between the expression of MCM5 and clinical pathological characteristics was analyzed. [Results]The expression of MCM5 increased from CIN to cervical squamous cell carcinoma. The LI median of MCM5 in CIN Ⅰ, CIN Ⅱ, CIN Ⅲ and cervical squanous cell carcinoma was 36.45%, 60.43%, 79.52% and 90.34%, respectively, and the difference among 4 groups had statistical significance（ P 〈0.01）. But there was no statistical significance in FIGO stage, age and lymph node metastasis among 4 groups（ P 〉0.05）. [Conclusion]MCM5 is a new indicator of cell proliferation, and can he served as a reference index. Its expression is associated with differentiation of cervical squamous cell carcinoma.
出处
《医学临床研究》
CAS
2010年第12期2204-2206,共3页
Journal of Clinical Research
