摘要
目的研究P53、c-myc、bcl-2三种癌基因蛋白的表达在宫颈癌放疗中的预后价值。方法采用免疫组化ABC法检测叙例放疗未控以及与之配对的40例放疗治愈的宫颈癌患者中三种癌基因蛋白的表达。结果未控组和治愈组产表达无明显差异（52．5％VS42.5％，P＞0．05），未控组中C－myc表达明显高于治愈组（72．5％VS42．5％，P＜0．01）bcl－2表达却明显低于治愈组（20．0％VS45．0％，P＜0．05）。结论放疗前检测宫颈癌活检标本中心c-myc、bcl-2蛋白的表达可作为判断预后的参考指标。
the pldgnshc value of the expression of P53, c-myc and bcl-2 protein incervical oninorna beted with radiotherapy. Methwh The expassion of Ihese tha oncoproteins was detcdtedistochendcally in 4 uncontldled cases and 4 matched cuwhle cases. Results The study shawed thatP53 oncorotein expression was not signilicant difference between the two gldups. c-myc expression wassignilicantly higher in tLhe unconbolled gldup than in the culable gldup and bcl-2 expression lowr in the formerthan in the latter. condbon It is suggested that the deteetion of c-myc and bel-2 oncoproteins in cewicalcareinoma before radiotherapy can be used to andet prognoois.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第6期422-423,共2页
Cancer Research on Prevention and Treatment
关键词
宫颈癌
癌基因蛋白
放射疗法
预后
Cervical carcinoma
Radiotherapy
Oncogene
Prognosis
