摘要
目的：了解喉部鳞状细胞表皮生长因子受体（EGF－R）mRNA的表达情况及其与喉部鳞癌的特征、组织分化的关系。方法：用斑点杂交法检测20例喉鳞状细胞癌活体标本。结果：15例出现EGF－RmRNA表达，其表达率为75％。EGF－RmRNA表达与患者年龄、肿瘤的部位无关，而与TNM分期、组织分化程度有关，T3，T4期的表达高于T1，T2期（P＜0．05）；分化程度低的肿瘤，其EGF－RmRNA表达高于分化程度中等和高分化者。4例复发癌均为高表达，6例伴颈淋巴结转移者亦均为高表达。结论：EGF－RmRNA表达与喉鳞状细胞癌的癌细胞无限制生长、分裂机制有一定关系；EGF－RmRNA高表达与晚期低分化喉鳞癌有较大的相关性。
Objective:To study the expression of the epidermal growth factor-receptor (EGF-R ) mRNA in la-ryngeal squamous cell carcinoma and its correlation with clinical characteristic and difference of tissues. Method:All 20 samples of laryngeal squamous cell carcinoma were determined by dot blot. Result: The EGF-R mRNA ex-pression was evaluated in 20 laryngeal squamous cell carcinomas and 15(75% ) were finded with EGF-R mRNAexpression. When the mRNA of the laryngeal squmous cell carcinorna was decreased,the expression of the EGF-R mRNA was decreased. The EGF-R mRNA expression did not correlated with age or tumor localization (P >0. 05)but correlated with differentiated tumors (P <0. 05) and the stages of TNM according to classification (P< 0. 05). Four patients with recuence cancers and six patients with the metastatic cervical-lymph-node involve-ment had an enhanced expression of EGF-R mRNA. Coudusion: The uncontrolled growth and proliferation of thelargugeal squmous cell carcinomas may be related to the abnormal EGF-R mRNA expression. The enhanced ex-pression of EGF-R mRNA was correlated with the differentiation and stages of laryngeal squmous cell carcino-mas.
出处
《临床耳鼻咽喉科杂志》
CSCD
1999年第12期549-551,共3页
Journal of Clinical Otorhinolaryngology
关键词
喉鳞状细胞
MRNA
喉肿瘤
EGF-R
Laryngeal squamous cell carcinomas Epidermal growth factor-receptor mRNA Laryngeal neoplasms
