摘要
目的:评价奥美沙坦酯治疗老年高血压的疗效和安全性。方法:选取2009年1-8月我院42例老年高血压患者,随机分为两组。治疗组(21例)服用奥美沙坦酯每次20mg,每日1次;对照组(21例)服用氯沙坦每次50mg,每日1次。总疗程均为8周。结果:奥美沙坦酯组和氯沙坦组治疗前后血压下降幅度差异均有统计学意义(P<0.01)。奥美沙坦酯组和氯沙坦组降压显效率分别为69.0%和68.4%,总有效率分别为90.4%和89.7%,两组间差异无统计学意义(P>0.05)。奥美沙坦酯组和氯沙坦组均未出现药品不良反应。结论:奥美沙坦酯治疗老年高血压效果明显,安全性好。
Objective：To evaluate the efficacy and safety of olmesartan medoxomil on hypertension in elderly patients.Methods：Forty-two patients collected in our hospital from January to August in 2009 were randomly divided into two groups.The treatment group（21 patients） received olmesartan medoxomil 20 mg once daily,and the control group（21 patients） were given losartan 50 mg once daily.All patients were treated for 8 weeks.Results：Both systolic and diastolic blood pressure decreased significantly from baseline to the end in the two groups（P 0.01）.The markedly effective rate was 69.0% in olmesartan medoxomil group,and 68.4% in losartan group.The total effective rate was 90.4% in olmesartan medoxomil group,and 89.7% in losartan group.There was no significant difference between two groups in the efficacy（P 0.05）.No adverse drug reaction was observed in both groups.Conclusion：Olmesartan medoxomil is effective and safe in the treatment of hypertension in elderly patients.
出处
《中国药物应用与监测》
CAS
2010年第6期332-334,共3页
Chinese Journal of Drug Application and Monitoring
关键词
奥美沙坦酯
氯沙坦
老年患者
高血压
疗效观察
Olmesartan medoxomil
Losartan
Elderly patient
Hypertension
Efficacy observation
