摘要
以性状、溶出度、有关物质和含量为考察项目,通过影响因素实验、加速实验和长期实验对癸氧喹酯固体分散体进行稳定性考察.结果:影响因素实验中癸氧喹酯固体分散体吸湿性比较明显,但溶出度、有关物质和含量均无明显变化;加速实验和长期实验中癸氧喹酯固体分散体的性状、溶出度和含量基本不变,没有出现新的降解物质.结果表明癸氧喹酯固体分散体质量可控,稳定性较好.
Taking character,dissolution rate,related substance and content of decoquinate as study projects,this paper studyed the stability of decoquinate solid dispersion under influential factor test,accelerated test and long-term experiment.The results show in the influential factor test,the hygroscopicity of decoquinate solid dispersion was obvious,however,its dissolution rate,related substance and content had no significant change;The character,dissolution rate,and content remain unchanged,and there are no new degradation products in the accelerated test and long-term experiment.The results showed that both the quality and stability of decoquinate solid dispersion are good.
出处
《武汉工程大学学报》
CAS
2010年第12期18-22,共5页
Journal of Wuhan Institute of Technology
