摘要
近十年来,抵抗素作为新近发现的一种脂肪细胞因子,被认为是联系肥胖、胰岛素抵抗及2型糖尿病的一种激素。多数动物实验发现抵抗素可引起胰岛素抵抗,且与肥胖、糖尿病有关,但目前临床研究结果尚存争议,并且对于抵抗素在人体内确切的生理作用机制尚不明了。本文就抵抗素与胰岛素抵抗、肥胖及2型糖尿病的关系研究进展进行综述。
Over the past decade,resistin,as a novel adipokine,is regarded to link insulin resistance,obesity and type 2 diabetes.Many studies on rodents showed that resistin caused insulin resistance in mice and was associated with obesity and diabetes.However,the role of resistin in human disease remains controversial.The physiological functions of resistin are unknown at present.On the other hand,current evidence appears to suggest that resistin is a kind of proinflammatory cytokine.This article reviewed the relationships among resistin,insulin resistance,obesity and type 2 diabetes.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第36期4158-4160,共3页
Chinese General Practice
关键词
抵抗素
胰岛素抵抗
肥胖症
糖尿病
2型
Resistin
Insulin resistance
Obesity
Diabetes mellitus
type 2
