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胰岛素样生长因子1、胰岛素抵抗与前列腺体积的相关性分析 被引量：3

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摘要 目的探讨胰岛素样生长因子1(Insulin-like growthfactor1,IGF-1)、胰岛素抵抗程度与前列腺体积的相关性。方法收集我院老年病科良性前列腺增生症(benign prostatic hyperplasia,BPH)患者90例,根据下尿路症状(lower urinary tract symptoms,LUTS)、国际前列腺症状评分(international prostate symptoms score,IPSS)、前列腺特异性抗原(prostate specific antigen,PSA)以及经腹超声前列腺体积测定分为观察组和对照组。观察组有下尿路症状且IPSS为中重度症状并确诊为BPH,对照组没有下尿路症状。收集这些患者的一般资料和生化特征。结果与对照组相比,观察组的空腹血糖(FBG)[(6.29±0.77)vs(4.77±0.33)mmol/L]、空腹胰岛素(FINS)[(12.92±3.81)vs(8.49±2.04)mU/L]、胰岛素抵抗指数(HOMA-IR)[(3.60±1.27)vs(1.89±0.36)]、低密度脂蛋白(LDL-c)[(3.74±0.37)vs(2.05±0.48)mmol/L]水平较高(P<0.05),而IGF-1[(104.63±26.14)vs(169.78±53.70)μg/L]与高密度脂蛋白(HDL-c)[(1.12±0.20)vs(1.75±0.21)mmol/L]水平较低(P<0.01)。结论 IGF-1、胰岛素抵抗与前列腺增生的程度有关,是BPH发生、发展的危险因素。
作者 田勇 李华 陈素芳 李伟芳 臧宾宾 杨再刚
机构地区 郑州大学第一附属医院老年内分泌科
出处 《第三军医大学学报》 CAS CSCD 北大核心 2011年第4期426-427,共2页 Journal of Third Military Medical University
关键词 胰岛素样生长因子1 胰岛素抵抗 良性前列腺增生症
分类号 R195.4 [医药卫生—卫生统计学] R362 [医药卫生—病理学]
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参考文献10

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二级参考文献7

共引文献37

同被引文献28

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第三军医大学学报
2011年 第4期

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