Mapping and localization of susceptible genes in asthma 被引量：1

Mapping and localization of susceptible genes in asthma

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摘要 Objective To elucidate the development of mapping and localization of susceptible genes on chromosomes to asthma related phenotypes. Data sources Published articles about susceptibility genes for asthma related phenotypes were selected using PubMed. Study selection Using methods of candidate gene positional clone and genome-wide scan with linkage and association analysis to determine the location in the genome of susceptibility genes to asthma and asthma related phenotypes. Results There are multiple regions in the genome harboring susceptibility genes to asthma and asthma related phenotypes, including chromosomes 5, 11, 12, 6, 2, 3, 13, 7, 14, 9, 19 and 17. Many of these regions contain candidate genes involved in asthma development and progression. Some susceptible genes may affect the phenotype expression or response to therapy. In addition, the interaction of multiple genes with the environment may contribute to the susceptibility to asthma. Conclusions As an essential step toward cloning the susceptible genes to asthma, fine mapping and localization on chromosomes are definitely needed. Novel powerful tools for gene discovery and the integration of genetics, biology and bioinformatics should be pursued. Objective To elucidate the development of mapping and localization of susceptible genes on chromosomes to asthma related phenotypes. Data sources Published articles about susceptibility genes for asthma related phenotypes were selected using PubMed. Study selection Using methods of candidate gene positional clone and genome-wide scan with linkage and association analysis to determine the location in the genome of susceptibility genes to asthma and asthma related phenotypes. Results There are multiple regions in the genome harboring susceptibility genes to asthma and asthma related phenotypes, including chromosomes 5, 11, 12, 6, 2, 3, 13, 7, 14, 9, 19 and 17. Many of these regions contain candidate genes involved in asthma development and progression. Some susceptible genes may affect the phenotype expression or response to therapy. In addition, the interaction of multiple genes with the environment may contribute to the susceptibility to asthma. Conclusions As an essential step toward cloning the susceptible genes to asthma, fine mapping and localization on chromosomes are definitely needed. Novel powerful tools for gene discovery and the integration of genetics, biology and bioinformatics should be pursued.

作者 GU Ming-liang ZHAO Jing

机构地区 Beijing Institute of Genomics Key Laboratory of Genome Science and Information Center for Asthma Prevention and Control

出处《Chinese Medical Journal》 SCIE CAS CSCD 2011年第1期132-143,共12页 中华医学杂志（英文版）

关键词 susceptible gene CHROMOSOME MAPPING LOCALIZATION ASTHMA susceptible gene chromosome mapping localization asthma

分类号 S511 [农业科学—作物学] S856.3 [农业科学—临床兽医学]

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1Masoli M,Fabian D,Holt S,Beasley R.The global burden of asthma:executive summary of the GIAN Dissemination Committee Report.Allergy 2004; 59:469-478.
2Beasley R.The burden of asthma with specific reference to the United States.J Allergy Clin Immunol 2002; 109 (5 Suppl):S482-S489.
3Ober C,Hoffjan S.Asthma genetics 2006:the long and winding road to gene discovery.Genes Immunol 2006; 7:95-100.
4Townley RG,Bewtra A,Wilson AF,Hopp RJ,Elston RC,Nair N,et al.Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma.J Allergy Clin Immunol 1986; 77:101-107.
5Longo G,Strinati R,Poli F,Fumi F.Genetic factors in nonspecific bronchial hyperreactivity:an epidemiologic study.Am J Dis Child 1987; 141:331-334.
6Postma DS,Bleecker ER,Amelung PJ,Holroyd KJ,Xu J,Panhuysen CI,et al.Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy.N Engl J Med 1995; 333:894-900.
7Noguchi E,Shibasaki M,Arinami T,Takeda K,Maki T,Miyamoto T,et al.Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population.Am J Respir Crit Care Med 1997; 156:1390-1393.
8Yokouchi Y,Nukaga Y,Shibasaki M,Noguchi E,Kimura K,Ito S,et al.Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families.Genomics 2000; 66:152-160.
9Martinez FD,Solomon S,Holberg CJ,Graves PE,Baldini M,Erickson RP.Linkage of circulating eosinophils to markers on chromosome 5q.Am J Respir Crit Care Med 1998; 158:1739-1744.
10Ober C,Cox NJ,Abney M,Di Rienzo A,Lander ES,Changyaleket B,et al.Genome-wide search for asthma susceptibility loci in a founder population.Hum Mol Genet 1998; 7:1393-1398.