Differential Electrolytic Potentiometric, a Detector for FIA Determination of Procainamide in Pharmaceutical Preparations
Differential Electrolytic Potentiometric, a Detector for FIA Determination of Procainamide in Pharmaceutical Preparations
摘要
Differential electrolytic potentiometry （DEP） was coupled with Flow injection analysis （FIA） technique for the determination of Procainamide in pharmaceutical preparations. Platinum electrodes were used as an indicating system to follow the oxidation of Procainamide with cerium（IV）, and permanganate in an acidic medium. The oxidation reactions of Procainamide with Ce（IV） and/or permanganate are fast enough to permit its determination by flow injection in sulfuric acid media. The univariate method was employed to optimize the variables such as the current density, the flow rate, the oxidant concentration and the concentration of sulfuric acid. The proposed method was linear in the range 20-100 μg.mL^-1 , the DL and R2 values were 12 μg.mL^-1 and 0.995 respectively. The procedure was applied successfully to the determination of Procainamide in commercial tablets. The results of this study were favorably compared statistically with those obtained with official methods.
参考文献29
-
1A. Osol, R. Pratt, The United States Dispensatory, 27th ed., Philadelphia, J.B. Lippincott Company, 1980.
-
2S.R. El-shabouri, A.F. Yousif, F.A. Mohamed, A.M.I. Rageh, Colorimetric determination of C-2 unsubstituted phenothiazines, using morpholine and N-bromosuccinimide, J. Assoc. off. Anal. Chem. 69 (1986) 821.
-
3M.S. Mahrous, M.M. Abdel-Khalek, Spectrophotometric determination of phenothiazines, tetracyclines and chloramphenicol with sodium cobaltinitrite, Talanta 31 (1984) 289.
-
4P.G. Ramappa, H.S. Gowda, A.N. Nayak, Tungstophosphoric acid as a new reagent for the spectrophotometric determination of phenothiazines, J. Michrochem. 28 (1983) 586.
-
5M. Rizk, N.A. Zakhari, F. Ibrahim, M.I. Walash, Spectrophotometric titration of phenothiazines using -2,3dichloro-5,6-dicyano-1,4-benzoqunone, Talanta 1 (1989) 355.
-
6Rizk, N.A. Zakhari, F. Ibrahim, M.I. Walash, Determination of phenothiazines by charge-transfer complex formation with chloranilic acid M, Talanta 33 (1986) 111.
-
7M. D'Sousa Gayarama, H.S. Yathirajan, Y. Rangaswam, Interaction of phenothiazines with nitroso-R salt and extractive spectrophotometric determination of phenothiazine, Drugs Ibid. 33 (1986) 352.
-
8M.A. Koupparis, A. Barcuchova, Automated flow injection spectrophotometric determination of some phenothiazines using iron perchlorate: applications in drug assays, content uniformity and dissolution studies, Analyst 111 (1986)313.
-
9C.S.P. Sastry, R.T. Thirupathi, A. Sailaja, Spectrophotometric methods for the determination of procainamide hydrochloride in tablet, Indian Journal of Pharmaceutical Sciences 53 (1991) 249-51.
-
10A.M.I. Mohamed, H.Y. Hassan, H.A. Mohamed, S.A. Hussein, Use of 7,7,8,8-tetracyanoquinodimethane for spectrophotometric determination of certain local anesthetics and procainamide hydrochloride, Journal of Pharmaceutical and Biomedical Analysis 7 (1991) 525-30.
-
1Tatar Ulu,Sevgi.High Performance Liquid Chromatography for the Determina- tion of Metoclopramide in Pharmaceutical Preparations Using Pre-column Derivatization with Fluorescamine[J].Chinese Journal of Chemistry,2012,30(3):634-638. 被引量：1
-
2普鲁卡因环保压力逼退部分产能[J].制药原料及中间体,2011(12):13-15.
-
3王敬敏,刘永芬.用于药物制剂的冷冻干燥技术及相关影响因素[J].科学与财富,2014,0(7):282-282. 被引量：2
-
4张夕村,曾菲菲.流动注射分析法测定磺胺类药物含量[J].沈阳化工,1991(3):24-27.
-
5李青山,岑军辉,张嗣良,李凡超,俞俊棠.固定化青霉素酶反应器流动注射碘量法快速测定青霉素[J].中国抗生素杂志,1994,19(5):340-343. 被引量：1
-
6姜丹,付永胜,何勇峰,武强.流动注射分析法测定成烟产物中的Zn^2＋[J].防化研究,2005(4):34-38.
-
7赖昌辉,蔡惠业,蔡晓红.表面活性剂和洗涤剂[J].精细石油化工文摘,1997(9):7-19.
-
8于珍祥.流动注射分析法在表面活性剂行业中的应用[J].日用化学工业,1992,22(6):38-43.
-
9许庆琴.大孔径毛细管气相色谱法快速测定饮料中的普鲁卡因[J].浙江师范大学学报（自然科学版）,2002,25(1):39-40.
-
10朱显峰,余晨晨,范书军,秦仁炳,张晶晶.蜜环菌水溶性多糖的抗氧化活性研究[J].食品工业科技,2012,33(3):89-91. 被引量：12
