摘要
目的： 检测血管内皮生长因子（ＶＥＧＦ） 及其受体（ＫＤＲ） 在卵巢癌中的表达， 并探讨其与卵巢癌发生的关系。方法： 采用ＳＡＢＣ免疫组化染色法， 对６６ 例卵巢肿瘤中， ＶＥＧＦ 和ＫＤＲ 的表达进行检测。结果： 恶性、交界性及良性卵巢肿瘤中， ＶＥＧＦ 和ＫＤＲ 的表达率分别为７２－９％ 、７５－００ ％ 、３８－４６ ％ 及５４－０５％ 、４３－７５％ 、７－６９ ％ ； 恶性肿瘤及交界性肿瘤ＶＥＧＦ和ＫＤＲ的表达， 明显高于良性肿瘤（Ｐ＜ ０－０５） 。ＫＤＲ 不仅表达于肿瘤血管内皮细胞， 在肿瘤细胞内也有强表达。有淋巴结转移的卵巢癌ＶＥＧＦ 的表达与无淋巴结转移者相比较， 有显著差异（Ｐ＜ ０－０５）； ＫＤＲ 的表达与卵巢癌淋巴结转移无关（Ｐ＞ ０－０５）； 卵巢癌的不同临床分期、病理类型及病理分级间ＶＥＧＦ和ＫＤＲ的表达， 无显著性差异（ Ｐ＞ ０－０５） 。结论： ＶＥＧＦ和ＫＤＲ 的表达可能与卵巢癌的发生有关。
Aim:To examine the expression of VEGF and its receptor KDR in ovarian cancer and to explore its relationship with occurrence of ovarian cancer Methods: VEGF and KDR expressions in 66 samples of ovarian tumor were observed by SABC immunohistochemical staining Results: The positive rates of VEGF and KDR expression among malignant, borderline and benign tumors were 72 97%, 75 00%, 38 46%and 54 05%, 47 35%, 7 69%,respectively The VEGF and KDR expression in malignant and borderline tumors was, obviously higher then that in benign tumor(P<0 05) KDR was localized both in tumor cells and vascular endothelial cells Lymph node metastasis of ovarian cancer had good relation to VEGF expression(P<0 05), but not to KDR expression(P>0 05)VEGF and KDR expression was not related to clinical stages,pathological types as well as pathological grades(P>0 05) Conclusion: VEGF and KDR expression might be one cause of formation of ovarian cancer
出处
《细胞与分子免疫学杂志》
CAS
CSCD
1999年第4期269-271,共3页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金!资助项目
No-39700147
