摘要
目的探讨肌钙蛋白T(TnT)及超声心动图对病毒性心肌炎(VMC)的诊断价值。方法经所有患者知情同意后,对35例VMC患者(重症12例,轻症23例)和30例健康对照者,在入院24 h内检测TnT及心肌酶谱,进行对比分析;随访发病6个月后的超声心动图变化。结果 VMC患者中,入院24 h内TnT的阳性率(94.29%)显著高于其他各项心肌酶谱(CK、CK-MB、AST、LDH),VMC患者在早期时与对照组比较均有左室收缩功能的下降,并且所有VMC患者均有左室舒张末期内径扩大及室间隔增厚,而轻症患者与重症组比较左室舒张末期内径增大更明显(P<0.05)、室间隔接近正常(P<0.05);6个月后,重症患者超声心动图的上述指标的恢复幅度较轻症患者更显著(P<0.05)。结论 TnT在VMC的诊断中具有较高的特异性及敏感性,并且超声心动图对VMC的病情判断、临床预后具有一定的应用价值。
Objective To explore the diagnostic values of troponin T（TnT） and echocardiography in viral myocarditis（VMC）.Methods After informed consent,35 cases of VMC（12 severe cases,23 mild cases）and 30 healthy subjects received TnT and myocardial enzymogram measurement within 24 h of admission.The results were analyzed and compared each other.Echocardiographic changes 6 months after onset were followed up.Results TnT positive rate（94.29%） of VMC patients admitted within 24 h was significantly higher than that of the myocardial enzymogram（CK,CK-MB,AST,LDH）（P0.05）.VMC patients in early stage were of decreased left ventricular systolic function compared with the control group.All patients had enlarged left ventricular diastolic diameter and thickening interventricular septum,but left ventricular end diastolic diameter in mild patients increased more significantly（P0.05） and their interventricular septums were close to normal（P0.05） compared with those in the severe ones.After 6 months,the above echocardiographic indicators of severe patients recovered more significantly than those of mild patients（P0.05）.Conclusion TnT is of high specificity and sensitivity in the diagnosis of VMC.Echocardiography may have certain values in the judgment of pathogenetic condition and prognosis of VMC.
出处
《西南国防医药》
CAS
2011年第1期30-32,共3页
Medical Journal of National Defending Forces in Southwest China
