摘要
目的:探讨诊断性刮宫(诊刮)术后分别应用米非司酮和安宫黄体酮治疗围绝经期功能失调性子宫出血(功血)的临床疗效。方法:收集诊刮术后分别口服米非司酮和安宫黄体酮的围绝经期功血病例各40例,观察用药期间及停药后阴道流血情况、子宫内膜厚度及性激素的变化。结果:治疗期间两组患者阴道流血均得到一定的控制,米非司酮组治愈率较高,差异有显著性(P<0.05);两组治疗后子宫内膜厚度均变薄,差异有显著性(P<0.05);但米非司酮组抑制子宫内膜增生效果较好,两组差异有显著性(P<0.05);用药后米非司酮组显示FSH、LH、E2、P值均降低,差异有显著性(P<0.05),安宫黄体酮组无明显变化。结论:围绝经期功血患者,采用米非司酮治疗功血效果优于安宫黄体酮,且诱导闭经,效果显著。
Objective：To explore the curative effect of the using of mifepristone and medroxy progesterone acetate on perimenopause dysfunctinal uterine bleeding after diagnostic curettages.Methods：40 patients treated by mifepristone and 40 patients treated by medroxy progesterone acetate were selected for treating perimenopause dysfunctional uterine bleeding after diagnostic curettages.Uterine bleeding and the thickness of endometrium and the variations of endocrine were observed during the drug-administering period and after the course of treatment ended.Results：Two groups＇s symptom of bleeding were controlled,cure rate of mifepristone was higher than the contrast group（P0.05）.The thickness of endometrium of two groups decreased after treating.Mifepristone group＇s curative effect of controlling endomcetrium hyperplasia was better than the the contrast group（P0.05）.Sex hormore including of FSH,LH,E2 and P decreased in mifepristone group after treatment.Contrast group＇s Sex hormore was not changed（P0.05）.Conclusion：Curative effect of mifepristone group is better than the contrast group in treatment of patients with perimenopause dysfunctional uterine bleeding,it has significant effect to use mifepristone to induce amenorrhea.
出处
《医学理论与实践》
2011年第2期139-141,共3页
The Journal of Medical Theory and Practice
关键词
围绝经期功血
米非司酮
安宫黄体酮
Perimenopause dysfunctional uterine bleeding
Mifepristone
Medroxy progesterone acetate
