摘要
将介孔58S生物活性玻璃(m58S)作为抗癌药物载体评价了其对表阿霉素的装载量和释放性能.实验结果表明,m58S对亲水性药物表阿霉素的药物装载量为40%,是普通溶胶-凝胶58S生物活性玻璃的3倍多,并且具有更长效的缓释特性.研究还发现释放介质的pH值对表阿霉素的释放速率有很大影响,pH值越低,表阿霉素分子从载体材料中释放出的速率越快.因此,介孔生物活性玻璃是一种高效的药物缓释载体,且药物释放速率受释放介质pH值影响,有望成为药物控释型骨修复材料.
Mesoporous bioactive glasses m58S were loaded with an anticancer drug-Epirubicin hydrochloride（EPI） and the release of the drug from the glasses was evaluated.The drug loading capacity of m58S for EPI was 40%, which was three times higher than that of conventional Sol-Gel bioactive glasses 58S.In phosphate buffered saline （PBS）,the m58S-EPI system showed a sustained release behavior.Furthermore,the release rates from the EPI-m58S system increased with the decrease of pH values of the release medium.The results suggest that m58S is an effective anticancer drug carrier and its pH-related release behavior suggests that it has potential for design of controlled drug delivery bone grafting materials.
出处
《无机材料学报》
SCIE
EI
CAS
CSCD
北大核心
2011年第1期68-72,共5页
Journal of Inorganic Materials
基金
国家重点基础研究发展973计划(2005cB522704)
国家自然科学基金(30730034)
上海市基础研究重点项目(08JC1420800)
国家高技术研究发展863计划(2007AA032317)~~
关键词
生物活性玻璃
介孔材料
药物载体
bioactive glasses
mesoporous materials
drug delivery system
