摘要
目的探讨血小板衍生生长因子B链(PDGF-B)及受体α链(PDGFR-α)与非小细胞肺癌发生发展的关系。方法采用免疫组化LSAB法检测PDGF-B、PDGFR-α在85例非小细胞肺癌原发灶以及20例正常支气管黏膜中的表达。结果 PDGF-B在非小细胞肺癌(NSCLC)细胞浆和/或细胞核中表达,PDGFR-α主要在NSCLC细胞浆中表达,个别在细胞核表达;与正常支气管粘膜组织相比,PDGF-B、PDGFR-α在NSCLC均过度表达(P<0.05);高分化腺癌组PDGFR-α阳性表达率明显高于低分化腺癌组(P<0.05);Ⅱ、Ⅲ期肺癌组PDGF-B阳性表达率明显高于Ⅰ期肺癌组(P<0.05)。结论 PDGF-B/PDGFR-α自分泌刺激环在NSCLC的发生中可能起重要作用;PDGFR-α阳性表达与肺腺癌分化呈正相关;PDGF-B的阳性表达与肺腺癌、鳞癌临床分期呈正相关。
We aimed to study the roles of platelet-derived growth factor B chain（PDGF-B） and platelet-derived growth factor receptor alpha（PDGFR-α） in non-small cell lung cancer（NSCLC）.We detected the expression of PDGF-B and PDGFR-α in 85 cases of NSCLC and 20 cases of normal bronchial epithelium with LSAB immunohistochemical technique.In NSCLC,the expression of PDGF-B was located in cytoplasm and/or nucleolus of tumor cells,while PDGFR-α mainly in cytoplasm,and a few in nucleolus.Compared with normal bronchial epithelium,the expressions of PDGF-B and PDGFR-α were much higher in NSCLC（P〈0.05）;the expression of PDGFR-α in well differentiated adenocarcinoma（ADC） of lung was higher than that in poor differentiated ADC（P〈0.05）;the expression of PDGF-B in Ⅱ and Ⅲ stages of ADC and squamous carcinoma（SQC） of lung was much higher than that in Ⅰstage.The results suggest that PDGF-B/PDGFR-α autocrine-stimulated loop may play a crucial role in the development of NSCLC.And PDGFR-α has a positive relationship with the differentiation of ADC,while PDGF-B has a positive relationship with the clinical stages in ADC and SQC of lung.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2011年第1期66-69,共4页
Immunological Journal
