摘要
目的:研究沙棘果醇提物和水提物对高脂血症模型小鼠的调血脂作用。方法:以喂饲普通饲料作为正常对照组,以高脂血症小鼠作为模型组,以1000、500和250mg·kg-1ig剂量的沙棘果醇提物和水提物为实验组,测定血清中的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)含量。结果:模型组TC、TG水平显著高于正常对照组(P<0.01);与模型组比较,不同剂量沙棘果醇提物可显著降低TC水平(P<0.01);不同剂量沙棘果醇提物与水提物可显著降低TG水平(P<0.05或P<0.01),对高脂血症模型小鼠血清中HDL-C无升高作用。结论:沙棘果提取物具有明显的调血脂作用,可用于高脂血症的预防和治疗。
OBJECTIVE：To explore the effect of the ethanol extract and water extract of Hippophae rhamnoides fruits on regulating blood lipid in hyperlipemia mice. METHODS： Normal control group was treated with common diet, experimental hyperlipemia mice were model group. The hyperlipemia mice were raised with ethanol extract and water extract of/L. rhamnlides fruits at the dose of 1 000, 500 and 250 mg·kg^-1 as experiment group. The levels of total chholesterin（TC） ,triglyeride （TG）,high lipoprotein cholesterol （HDL-C） in serum were all tested. RESULTS： The level of TC and TG in model group were higher than in normal control group（P〈0.01）.Compared with model group, the level of the TC decreased significantly in the different dose ethanol extract of H. rhamnoides fruits group （P〈0.01）. The level of TG decreased significantly in different dose of ethanol extract and water extract of H rhamnoides fruits （P〈0.05 or P〈0.01）, and it was not obvious effect on the level of HDL-C in serum. CONCLUSION： The extracts of H. rhamnoides fruits have significantly effccts on regulating blood lipid. It can prevent and cure the hyperlipemia.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第7期586-588,共3页
China Pharmacy
关键词
沙棘果
胆固醇
甘油三酯
高密度脂蛋白
高脂血症
Hippophae rhamnoides fruits
Cholesterol
Triglyceride
High density lipoprotein
Hyperlipemia
