期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

SERCA2a基因转导治疗心力衰竭的研究进展 被引量：6

暂未订购
导出
摘要 随着社会人口老龄化进程的不断加快,各种类型的心血管疾病导致的慢性心力衰竭逐渐增多。20世纪发展起来的转基因技术为心力衰竭的治疗寻找到了一个新的突破口。本文就SERCA2a(sarcoplasmic reticulum Ca2+-ATPase)及其基因的结构、功能以及SERCA2a基因在心力衰竭治疗方面的研究进展作一综述。
作者 陈礼斌 宫海滨
机构地区 东南大学医学院 徐州市心血管病研究所徐州市中心医院
出处 《东南大学学报（医学版）》 CAS 2010年第6期691-694,共4页 Journal of Southeast University(Medical Science Edition)
基金 国家自然科学基金资助项目(30572075) 江苏省医学135工程重点人才研究基金资助项目(RC2007024) 江苏省"六大人才高峰"资助项目 徐州市社会发展项目(XM09B073)
关键词 慢性心力衰竭 肌浆网Ca2+-ATP酶 基因治疗 综述
分类号 R541.6 [医药卫生—心血管疾病]
  • 相关文献

参考文献27

  • 1BRIXIUS K,FRANK K F,BOLCK B,et al.Reverse remodeling of the intracellular Ca2+ homeostasis:new concepts of pathophysiology and therapy of heart failure[J].Wien Med Wochenschr,2006,156(7-8):209-215.
  • 2MacLENNAN D H,BRANDL C J,KORCZAK B,et al.Amino acid sequence of a Ca2+/Mg2+ dependent ATPase from rabbit muscle sarcoplasmic reticulum,deduced from its complementary DNA sequence[J].Nature,1985,316(8):696-700.
  • 3BRANDL C J,GREEN N M,KORCZAK B,et al.Two Ca2+ ATPase genes.Homologies and mechanistic implications of deduced amino acid sequences[J].Cell,1986,44(4):597-607.
  • 4BRANDL C J,de LEON S,MARTIN D R,et al.Adult forms of the Ca2+ ATPase of the sarcoplasmic reticulum:expression in developing skeletal muscle[J].J Biol Chem,1987,262(3):3768-3774.
  • 5ZARAIN-HERZBERG A,MacLENNAN D H,PERIASAMY M.Characterization of rabbit cardiac sarco(endo)plasmic reticulum Ca2+ ATPase gene[J].J Biol Chem,1990,265(3):4670-4677.
  • 6GUNESKI-HAMBLIN A M,GREEB J,SHULL G E.A novel Ca2+ pump expressed in brain,kidney,and stomach is encoded by an alternative transcript of the slow-twitch sarcoplasmic reticulum Ca2+ ATPase gene[J].J Biol Chem,1988,263(29):15032-15040.
  • 7LYTTON J,ZARAIN-HERZBERG A,PERIASAMY M,et al.Molecular cloning of the mammalian smooth muscle sarco(endo)plasmic reticulum Ca2+ ATPase[J].J Biol Chem,1989,264(4):7059-7065.
  • 8BURK S E,LYTTON J,MacLENNAN D H,et al.cDNA cloning,functional expression and mRNA tissue distribution of a third organellar Ca2+ pump[J].J Biol Chem,1989,264(11):18561-18568.
  • 9FENG B.Structure,function and regulation of the sarcopplasmic reticulum Ca2+ ATPase[J].Pathophysiol Clin Med,1998,18(2):120-123.
  • 10ARAI M,YOGUCHI A,TAKIZAWA T,et al.Mechanism of doxornhicin induced inhibition of sarcoplasmic reticulum Ca(2+)-ATPase gene transcription[J].Circ Res,2000,86(1):8-14.

二级参考文献21

  • 1惠海鹏,李小鹰,彭江.大鼠经腹心包腔内注射术的研究[J].医学研究生学报,2005,18(10):879-881. 被引量：7
  • 2Schmidt U,Hajjar RJ,Kim CS,et al.Human heart failure:cAMP stimulation of SR Ca(2+)-ATPase activity and phosphorylation level of phospholamban.Am J Physiol,1999,277:H474-H480.
  • 3Schmidt U,Hajjar RJ,Helm PA,et al.Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure.J Mol Cell Cardiol,1998,30:1929-1937.
  • 4Miyamoto MI,del Monte F,Schmidt U,et al.Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure.Proc Natl Acad Sci USA,2000,97:793-798.
  • 5Hajjar RJ,Schmidt U,Matsui T,et al.Modulation of ventricular function through gene transfer in vivo.Proc Natl Acad Sci USA,1998,95:5251-5256.
  • 6Warren CM,Greaser ML.Method for cardiac myosin heavy chain separation by sodium dodecyl sulfate gel electrophoresis.Anal Biochem,2003,320:149-151.
  • 7Piao S,Yu F,Mihm MJ,et al.A simplified method for identification of human cardiac myosin heavy-chain isoforms.Biotechnol Appl Biochem,2003,37:27-30.
  • 8Yao A,Matsui H,Spkitzer KW,et al.Sarcoplasmic reticulum and Na/Ca exchanger function during early and late relaxation in ventricular myocytes.Am J Physiol,1997,273:H2765-H2773.
  • 9Lowes BD,Minobe W,Abraham WT,et al.Changes in gene expression in the intact human heart.Downregulation of alpha-myosin heavy chain in hypertrophied,failing ventricular myocardium.J Clin Invest,1997,100:2315-2324.
  • 10Meyer M,Trost SU,Bluhm WF,et al.Impaired sarcoplasmic reticulum function leads to contractile dysfunction and cardiac hypertrophy.Am J Physiol Heart Circ Physiol,2001,280:H2046-H2052.

共引文献21

同被引文献60

  • 1中华医学会心血管病学分会心力衰竭学组,中国医师协会心力衰竭专业委员会,中华心血管病杂志编辑委员会,杨杰孚,张健,韩雅玲.中国心力衰竭诊断和治疗指南2018[J].中华心力衰竭和心肌病杂志（中英文）,2018,2(4):196-225. 被引量：1005
  • 2李小鹰,惠海鹏,鲁晓春,郭豫涛.转基因过表达肌浆网钙ATP酶基因治疗慢性心力衰竭的实验研究[J].中华医学杂志,2006,86(17):1174-1178. 被引量：7
  • 3Williams PD, Ranjzad P, Kakar SJ, et al. Development of viral vectors for use in cardiovascular gene therapy[J].Viruses, 2010, 2(2):334-371.
  • 4Carter BJ. Adeno-assoeiated virus vectors in clinical trials[J]. Hum Gene Ther, 2005, 16(5):541-550.
  • 5Ly H, Kawase Y. Yoneyama R, et al. Gene therapy in the treatment of heart failure[J]. Physiology (Bethesda), 2007,22 (2):81-96.
  • 6Xu YJ, Chepman D, Dixon IM, et al. Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation[J]. J Cell Mol Med, 2004,8( 1 ) : 83-92.
  • 7del Monte F, Hajjar RJ, Harding SE. Overwhehning evidence of the beneficial effects of SERCA gene transfer in heart failure [J]. CircRes,2001,88(11):E66-E67.
  • 8Gheorghiade M, Ambrosy AP, Ferrandi M, et al. Combining SERCA2a activation and Na K ATPase inhibition: a promising new approach to managing acute heart failure syndromes with low cardiac output [J]. Discovery Medicine, 2011, 12 (63): 141-151.
  • 9Lipskaia L, Chernaly ER, Hadri L, et al. Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure [J]. Expert Opin Biol Ther, 2010,10(1):29-41.
  • 10Hajjar RJ, Zsebo K, Deckelbaum L, et al. Design of a phase 1/2 trial of intracoronary administration of AAV 1/SERCA2a inpatients with heart failure[J]. J Card Fail, 2008,14 ( 5 ): 355- 367.

引证文献6

二级引证文献30

东南大学学报（医学版）
2010年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部