摘要
目的观察胺碘酮联合普罗帕酮治疗室性期前收缩的疗效及安全性。方法将291例室性期前收缩患者随机分成3组,A组(65例)给予普罗帕酮片150mg口服,1次/8h。B组(68例)给予胺碘酮200mg口服,3次/d,1周后改为200mg口服,2次/d,再1周后改为200mg口服,1次/d。C组(68例)开始给予胺碘酮200mg口服,3次/d,普罗帕酮片150mg口服,1次/8h,治疗1周后,停用普罗帕酮片,同时胺碘酮改成200mg口服,2次/d,再1周后,胺碘酮改为200mg口服,1次/d。治疗周期均为3个月。结果住院期间,C组在控制室性期前收缩的时间上明显短于B组;出院后,C组在停药后的3个月里室性期前收缩复发率远低于A组。结论联合使用胺碘酮及普罗帕酮治疗室性期前收缩是安全有效的。
Objective To observe the efficacy and safety of combined use of amiodarone and propafenone in treating ventricular extrasystole. Methods 291 ventricular extrasystole patients were randomly assigned to three groups. Group A （65 cases） ： Propafenone tablet, orally, 150mg once every 8 hours. Group B （68 cases） ： Amiodaron, orally, start with 200mg three times daily for a week, then reduce to 200mg twice daily for the second week, and 200mg once daily for the third week. Croup C （68 cases） ： for oral administration, start with 200mg Amiodaron three times daily as well as 150mg Propafenone every 8 hours for a week; then adjust to 200mg Amiodaron twice daily and out of Propafenone tablet for the second week; and later 200mg Amiodaron once daily for the third week. The treatment of each group lasts for three months. Results During hospitali- zation, the time delay of group C in controlling ventricular extrasystole are signifieanfly shorter than that of group B. While after discharge from hospital, the relapse rate of group C is much lower than that of B in the period of three months after treatment withdrawal. Conclusion The combined use of Amiodaron and Propatenone is effective and safe in treating ventricular extrasystole.
出处
《实用心脑肺血管病杂志》
2011年第1期27-28,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
室性期前收缩
胺碘酮
普罗帕酮
Amiodaron
Propafenone
Ventricular extrasystole
