摘要
目的探讨环孢素A（CyA）在难治／复发性免疫性血小板减少症（ITP）治疗中的l性床疗效和不良反应。方法36例难治／复发ITP患者接受3～5mg／（kg·d）的CyA治疗并观察疗效和不良反应。结果中位随访10个月，完全反应（CR）13例（36．1％），有效（R）15例（41．7％），无效（NR）8例（22．2％），总有效率为77．8％。复发与难治两组疗效差异比较无统计学意义（P=0．083）。常见的不良反应为胃肠道反应、头痛、血压升高及肝功能受损，多数患者能较好耐受。结论低剂量的CyA治疗1TP是一种高效、安全的挽救性治疗方法，严重不良反应较少。
Objective To explore the efficacy and safety of Cyelosporine A （CyA） int the treatment of refractory/relapsed immune thromboeytopenia（ITP）. Methods Thirty -six patients with refractory/relapsed ITP were administered CyA with 3 - 5mg/（ kg· d）. Results The median follow up was ten months and the efficacy of the group was as follows： complete response in 13 （36.1% ） ,response （R） in 15 （41.7%）, non -response（NR） in 8（22.2% ）. There was no significant difference in the efficacy between the refractory and relapsed subgroups. The adverse events were mild and most patients could be well tolerated. Conclusion The high rate of responses and low and transient adverse events suggest that the oral administration of low dose CyA could be considered in severe, refractory/relapsed ITP as a salvage therapy.
出处
《医学研究杂志》
2010年第12期47-49,共3页
Journal of Medical Research
基金
全军医药卫生科研基金资助项目(08MA019)
