摘要
目的探讨增强型体外反搏（EECP）治疗对高血压并糖耐量减低（IGT）患者肱踝脉搏波传导速度（b8PWV）及血管内皮功能的影响。方法38例高血压并IGT患者分为常规治疗组（CT，20例）和常规治疗＋EECP组（CT＋EECP，18例）。CT＋EECP组隔天反搏治疗2h，总共反搏36h，共36d。分别于体外反搏前和反搏后检测baPWV，同时检测血浆内皮素（ET）、一氧化氮（NO）.结果CT组和CT＋EECP组治疗后baPWV明显下降，分别为1703±213（P〈0．05）和1601±208（P〈0．01），两组比较差异有统计学意义（p〈0．05）.两组患者经治疗后ET均明显下降（74．8±21．3和62．6±20．8，P〈0．05，P〈0．01），NO均明显上升（67．7：1：17．4和78．2±18．2，P〈0．05，P〈0．01）.CT＋EECP组baPWV和ET下降更为显著，下降幅度与常规治疗组比较差异有统计学意义（P〈0．05）。结论增强型体外反搏可改善高血压并IGT患者血管内皮功能，降低血管僵硬度，从而改善动脉弹性。
Objective To explore the effect of Enhanced External Counterpulsation （EECP） on pulse wave velocity （baPWV） and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance （IGT）. Methods Thirty-eight hypertensive patients complicated by IGT were randomly divided into 2 groups ： the conventional therapeutics group （ CT, n =20 ）, the conventional therapeutics ＋EECP group （ CT＋EECP, n=18）. EECP was performed on CT＋EECP group, 2 hours every other day lasting for 36 days. baPWV, Plasma ET, Nitric oxide（NO） were measured at the same time points in all patients. Results In CT＋EECP group, baPWV was decreased significantly （1601±208, P〈0.01 ） after treatment comparing to the CT group （1703±213, P〈 0.05）. Level of endothelin（ET） was significantly decreased in CT＋EECP group （62.6±20.8, P〈0.01 ）, comparing to the CT group[ （74.8±21.3）mg/L, P〈0.05 ] after 36-day treatment. However, level of Nitric oxide（NO） was significantly improved in CT＋EECP group （78.2±18.2, P〈0.01） comparing to the CT group （67.7±17.4）mg/L, P〈 0.05） after treatment. Conclusion EECP could improve endothelial function and artery elasticity in hypertensive patients complicated by IGT.
出处
《中国心血管病研究》
CAS
2011年第1期11-13,共3页
Chinese Journal of Cardiovascular Research
关键词
增强型体外反搏
高血压
脉搏波传导速度
糖耐量减低
内皮素
一氧化氮
Enhanced external counterpulsation （EECP）
Hypertension
Pulse wave velocity
Impaired glucose tolerance
Endothelin
Nitric oxide
