摘要
目的：研究柔红霉素聚氰基丙烯酸正丁酯毫微粒（ＤＮＲＰＢＣＡＮＰ）能否逆转白血病细胞的多药耐药性。方法：以噻唑蓝（ＭＴＴ）比色法评价ＤＮＲ，ＤＮＲＰＢＣＡＮＰ，ＰＢＣＡＮＰ对白血病细胞敏感株、耐药株的细胞毒性。结果：ＤＮＲ对耐药株的细胞毒作用降低８倍，而ＤＮＲＰＢＣＡＮＰ对敏感株、耐药株的细胞毒作用保持不变。结论：ＤＮＲＰＢＣＡＮＰ可逆转白血病细胞的多药耐药性。
BJECTIVE: To study the reversion of multidrug resistance of leukemic murine cells using daunorubicin polybutylcyanoacrylate nanoparticles (DNRPBCANP)in vitro. METHODS: The cytotoxicity of DNR, DNRPBCANP and PBCANP were determined by measuring the inhibition of cell growth using the tetrazolium dye (MTT) assay. RESULT: DNRPBCANP showed the same cytotoxic effect for sensitive and resistant cells, but free DNR decreased the cytotoxic effect in the case of resistant cells by 8 fold. CONCLUSION: DNRPBCANP was effective to overcome the multidrug resistance.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1999年第7期461-463,共3页
Chinese Pharmaceutical Journal
