摘要
目的：研究氟康唑滴眼液（ｆｌｕｃｏｎａｚｏｌｅｅｙｅｄｒｏｐｓ，ＦＣＺＥＤ）对兔眼实验性烟曲霉菌角膜溃疡的治疗作用。方法：测定ＦＣＺＥＤ对烟曲霉菌的最小抑菌浓度（ＭＩＣ）。取１０５ｃｆｕ·ｍｌ－１烟曲霉菌悬液２０μｌ，接种于兔眼角膜实质层，２４ｈ后随机分为４组，２，５ｇ·Ｌ－１ＦＣＺＥＤ；氟康唑静脉注射（ＦＣＺｉｖ）；生理氯化钠溶液对照，同时进行治疗。治疗结束，每组取４眼角膜，按霉菌总数平板测定法，计测菌落数。结果：ＦＣＺＥＤ对烟曲霉菌的ＭＩＣ值为０．１２５～０．２５ｇ·Ｌ－１。５ｇ·Ｌ－１ＦＣＺＥＤ治疗烟曲霉菌角膜溃疡与对照相比有显著疗效（Ｐ＜０．０１）。霉菌培养结果，５ｇ·Ｌ－１ＦＣＺＥＤ与对照组相比霉菌计数明显减少（Ｐ＜０．０１）。结论：５ｇ·Ｌ－１ＦＣＺＥＤ治疗实验性烟曲霉菌角膜溃疡有效。
BJECTIVE: To study the efficacy of fluconazole eye drops (FCZED) in the treatment of Aspergillus fumigatua corneal ulcer in rabbit. METHODS: The minimal inhibitive concentration(MIC) of FCZED to A. fumigatus was determined.20l of the 105 cfuml-1 A. fumigatus solution was inoculated to rabbit corneal stroma.The rabbits were then randomly divided into four groups and given 2gL-1 or 5gL-1 of FCZED ,FCZ iv,sodium chloride physiological solution(SCPS) respectively.After treatment,4 eyes of cornea in each group were taken,and fungal flating method were used to count cfuml-1. RESULTS: MIC of FCZED to A. fumigatus was 0.1250.25gL-1.The group of 5gL-1 FCZED showed more effective than control group in treating A. fumigatus corneal ulcer (P<0.01) with significant reduction (P<0.01). CONCLUSION: 5gL-1 FCZED appears to be effective in the treatment of A. fumigatus corneal ulcer.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1999年第7期456-458,共3页
Chinese Pharmaceutical Journal
