摘要
目的 探讨危重病人血浆甲状腺激素（ Ｔ Ｈ） 的变化及其临床意义。方法 应用放射免疫分析法测定７３ 例危重病人和６０ 例健康人（ 对照组） 的血浆 Ｔ Ｈ 含量。结果 危重病人血浆 Ｔ３／ Ｆ Ｔ３ 含量〔（１０５ ±０４６）ｎ ｍｏｌ／ Ｌ〕／〔（２８５ ±１４１）ｐｍｏｌ／ Ｌ〕明显低于对照组〔（１９８ ±０５１）ｎｍｏｌ／ Ｌ， Ｐ＜ ００１〕／〔（６３７ ±１３１）ｐｍｏｌ／ Ｌ， Ｐ＜０００１〕；死亡组 Ｔ３／ Ｆ Ｔ３ 水平与非死亡组 Ｔ３／ Ｆ Ｔ３ 水平相比较有显著差异（ Ｐ＜ ００５／ Ｐ＜ ００１） 。结论 Ｔ Ｈ 参与了危重病人的病理生理过程，监测危重病人血浆 Ｔ Ｈ 水平可作为反映病情程度和评估预后的一项参考指标。
Objective To valuate the clinical significance changes in plasma thyroid hormone (TH)in critically illness (CI)patients .Methods Plasma thyroid hormone concentrations were measured in 73 patients with critically illness and 60 healthy volunteers (control group)by radioimmunoassay. Results Plasma T 3 and FT 3 concentrations in critically illness patients 〔(1 05±0 46)nmol/L〕/〔(2 85±1 41)pmol/L〕were markedly lower than control group 〔(1 98±0 51)nmol/L, P< 0 01〕/〔(6 37±1 31)pmol/L, P< 0 001〕;the level of T 3/FT 3 were different significantly between death group and non-death group ( P< 0 05/ P< 0 01)respectively.Conclusions These results suggest TH may play an important role in the pathogenesis of critically illness .Measurement of plasma TH may be a useful parameter to predict severity and outcome of the illness. [
出处
《中国急救医学》
CAS
CSCD
北大核心
1999年第7期406-407,共2页
Chinese Journal of Critical Care Medicine
