摘要
微循环遍及全身,直接参与机体物质、能量与信息传递,与心、脑及外周血管疾病、糖尿病、结缔组织病及创伤、感染、休克等病理过程的发生、发展、疗效及预后判断关系密切,其功能改变涉及多种细胞因子与蛋白质组分之间动态、复杂、精细的相互作用。蛋白质组学作为一门研究细胞蛋白质的组成及其活动规律的新兴学科,有助于阐明生理或病理条件下的微循环改变的分子机制。本文综述近年来蛋白质组学技术进展及其在微循环研究中的应用。
Microcirculation spreads all over the body,participates in material,energy,and information transmission directly.It is closely related to pathogenesis,development and prognosis of heart,brain and peripheral vascular diseases,diabetes,connective tissue disease and participates in many pathological processes,such as trauma,infection and shock.Its function changes involve a variety of interactions between cytokines and proteins,which are dynamic,complex and subtle.As a new branch of science,proteomics investigates cell protein composition and interaction disciplines as a whole.This technology helps to clarify the molecular mechanism of microcirculation changes during physiological or pathological conditions.This paper reviews the recent progress of proteomics technology and its application in studies of microcirculation.
出处
《生理科学进展》
CAS
CSCD
北大核心
2010年第6期429-434,共6页
Progress in Physiological Sciences
基金
国家自然科学基金(81070186)资助课题
关键词
蛋白质组
质谱
微循环
内皮细胞
proteome
mass spectrometry
microcirculation
endotheliocyte
