摘要
目的探讨卵胞浆内单精子注射（intracytoplasmic sperm injection）出生婴幼儿与自然受孕（nature conceived）婴幼儿在1～3岁时的体格及精神运动发育有无差异。方法选取2006年1月~2008年7月在我院行ICSI技术后出生的1～3岁足月单胎试管婴儿70例,随机抽取同期出生的来我院门诊体检的1～3岁足月单胎NC婴幼儿80例,采用WHO推荐的0～6岁儿童身高、体重参考值及评价标准比较两组儿童的体格发育情况;用婴幼儿智能发育检查量表CDCC检测法比较两组儿童的精神运动发育情况。结果 （1）ICSI组出生体重稍低于NC组,差异无统计学意义。（2）两组儿童年龄别体重、年龄别身高、智力发育指数（MDI）、运动发育指数（PDI）比较无明显差异,但是对于MDI、PDI≤69分（发育迟缓）的比较,ICSI组发生率均低于NC组,差异有统计学意义（P〈0.05）。（3）母亲年龄、婚姻状况、家庭来源、家庭年收入、父母受教育程度对婴幼儿的身高体重发育的影响无统计学意义;但父亲教育程度对MDI的影响有统计学意义（P〈0.05）,对PDI的影响无统计学意义,其余各因素对MDI、PDI影响均无统计学意义。结论 （1）1～3岁足月单胎ICSI出生婴幼儿与足月单胎NC婴幼儿的体格发育和精神运动发育指标没有明显差别。（2）ICSI技术是相对安全的。
Objective To study the physical and psychomotor development of ICSI children at 1～3 years of age.Methods A total of 70 term-born singletons conceived by ICSI and 80 matched Nature conceived（NC） singletons at 1～3years of age participated voluntarily in the study.The physical and psychomotor development of the children conceived by ICSI or nature was evaluated.The child＇s physical developmental assessment is done with height and weight reference value of 0-6 years old children which recommend by WHO.The child＇s psychomotor developmental assessment is done with the Children Development Center of China（CDCC） scales of infant development.A matched control study was performed on physical and psychomotor development of two groups of children.The NC group was matched according to matemal age,Marital status,Family origin,Home economics situation,Parents educational level.Results（1）Compared to NC singletons,ICSI singletons＇birth weight is slightly lower than the NC ones,but the difference is not statistically significant.（2）There is also no significiant difference in the psychomotor development and physical development between the two groups.But for the comparison of the MDI,PDI≤69 points（those whose psychomotor development are lower than the normal）,ICSI group were lower than NC group,and the difference is statistically significant（P0.05）.（3）Maternal age,Marital status,Family origin,Home economics situation,Parents educational level had no significant influnence on physical development of children.5.Fathers＇education level had a statistical significance on children＇s MDI（t=2.409,P0.05）,but no statistical influence on the PDI.And Maternal age,Marital status,Family origin,Home economics situation are all had no significant influence on MDI and PDI.Conclusion（1）No significantly difference is found in the physical development and psychomotor development between NC and ICSI children born at term at 1～3 years of age.（2）The ICSI technology is comparatively safe.
出处
《江西医药》
CAS
2010年第11期1075-1077,共3页
Jiangxi Medical Journal
关键词
体格发育
精神运动发育
ICSI
试管婴儿
psychomotor development
physical development
ICSI
the children born after IVF-ET
