摘要
目的：研究胃粘膜相关淋巴组织型淋巴瘤的临床病理、免疫表型及与幽门螺杆菌的关系。方法：应用免疫组织化学ＬＳＡＢ法进行免疫分型，对ＭＡＬＴ型淋巴瘤和淋巴组织反应性增生进行鉴别，用Ｇｉｅｍｓａ染色显示幽门螺杆菌，对患者进行随访。结果：老年人胃的粘膜相关淋巴组织淋巴瘤均为单克隆Ｂ细胞起源，６８．４２％与幽门螺杆菌感染有关，与同期淋巴结内的非霍奇金淋巴瘤比较预后较好，差异有显著性（Ｐ＜０．０１）。结论：胃的粘膜相关淋巴组织型淋巴瘤与幽门螺杆菌的感染有关，临床在化疗同时应加用抗菌素。
Purpose To study the clinicopathology, immunophenotype of gastric mucosa associated lymphoid tissue (MALT) lymphoma and the ralationship between gastric MALT lymphoma and helicobacter pylori (Hp). Methods Immunohistochemical staining LSAB method was used to detect the immunophenotype and distinguish MALT type lymphoma from reactivited lymphnode. Giemsa staining was used to detect the Hp. All patients was followed up. Results Gastric MALT lymphoma in old patients was monoclonal B cell origin and 68 42% of them related to the infection of Hp. The biological behaviour in gastric MALT lymphoma was significantly better than that in lymph nodes at same stage.Conclusion Gastric MALT lymphoma correlates to Hp infection. Antibiotic should be used while chemotherapy is given.
出处
《临床与实验病理学杂志》
CAS
CSCD
1999年第1期18-20,I005,共4页
Chinese Journal of Clinical and Experimental Pathology
基金
山西省科学技术委员会资助课题
关键词
胃肿瘤
淋巴瘤
免疫表型
幽门螺杆菌
老年人
stomach neoplasms
lymphoma
immunophenotyping
helicobacter pylori
