摘要
用免疫组化ＳＰ法，检测１００例肺鳞状细胞癌手术标本中ｎｍ２３基因的表达。结果显示ｎｍ２３基因表达阳性率为７４．０％，明显高于癌旁组织（Ｐ＜０．０５）。ｎｍ２３基因表达与淋巴结转移及远处转移无关（Ｐ＞０．０５）；Ⅰ、Ⅱ期的阳性表达率明显低于Ⅲ、Ⅳ期，有非常显著性差异（Ｐ＜０．０１）；低分化癌的阳性表达率明显高于中分化及高分化癌，有非常显著性差异（Ｐ＜０．０１）。可以认为ｎｍ２３基因与肺癌的发生、发展有关，而不具有抑制转移功能。
With SP method,the expressions of nm23 gene were examined in 100 cases of lung squamous carcinoma.nm23 gene expression was positive in 74(74.0%) cases,it was significantly higher than that in nomal tissues(P<0.01),and it was related to the tumor differentiation and stage(P<0.01).But the expression of nm23 gene was not related to lymph node and distant metastasis.Therefore,our results indicate that the expression of nm23 gene may be implicate in the mechanism of carcinogenesis and progression.
出处
《实用癌症杂志》
1999年第2期99-100,共2页
The Practical Journal of Cancer
