摘要
目的研究卡维地洛与阿替洛尔治疗Ⅰ期或Ⅱ期高血压病的疗效比较。方法用随机、单盲、组间、平行对照的方法，用第三代β受体阻滞剂卡维地洛对高血压病患者进行为期4周的治疗观察，并与另一β1受体阻滞剂阿替洛尔进行对比，同时还进行了自身对照的治疗观察。卡维地溶剂量为10．00～4000mg／d，阿替洛尔为25.00～100．00mg／d，1次／d服用。结果通过78例的观察显示，两药降压总有效率无明显差异，不良反应均较少，但卡维地洛每天剂量比阿替洛尔小，其有数病例平均剂量为18.20mg／d。结论卡维地洛是一安全、有效的降压药。建议常用量为10.00～30.00mg／d。
Objective To investigate the efficacy of carvediol versus atenolol used in patients with mild andrnoderate essential hypertension. Methods A contrastive study was carried out in 78 patients with the treatment lasting 4 weeks,and radom,intergroup,parallel and single blind designs were resorted to as the contrastive methods. Results The total effective rates showed no remarkabIe difference between the two drugs on blood pressure reduction,while the daily dosage of carvediol was lower than that of atenolol. Adverse effects were relatively low in both drugs. The average dosage of carvediol in response cases was 18. 20mg/d. Conclusion This study verifies that carvediol is a safe and effective antihypertension agent,and the recommenteded dosage should be 10~30mg/d.
出处
《中国综合临床》
1999年第3期265-267,共3页
Clinical Medicine of China
