摘要
目的探讨结肠恶性肿瘤的超声造影(CEUS)增强模式及时间-强度曲线特点,分析CEUS定量参数与微血管密度(MVD)的相关性。方法对19例结肠恶性肿瘤患者行CEUS检查,观察病灶的增强模式,并利用时间-强度曲线获取肿瘤组织及瘤旁肠壁的定量参数。通过术后对肿瘤组织切片进行CD34染色,测得MVD,分析CEUS定量参数与MVD间的相关性。结果 CEUS示19例患者肿瘤均可见不同程度增强,以高增强为主。肿瘤组织与瘤旁肠壁的达峰时间(TTP)分别为(24.4±6.4)s及(31.3±7.6)s,绝对增强强度分别为(11.5±2.9)dB及(6.1±2.3)dB(P均<0.05)。16例患者肿瘤的时间-强度曲线表现为快速上升快速下降,2例呈快速上升缓慢下降,1例时间-强度曲线呈双峰。病灶的MVD值为(29.1±8.3)条;峰值强度(PI)及始增-达峰时间曲线下面积(AUCofATP)均与MVD呈正相关(r=0.80、0.74,P均<0.01)。结论 CEUS可以动态显示结肠恶性肿瘤的血流灌注情况,定量参数中PI、AUCofATP与肿瘤MVD具有较好的相关性,可用于术前评估肿瘤血管生成情况。
Objective To investigate the characteristics of the enhancement pattern and the time-intensity curve of malignant colonic tumors with contrast-enhanced ultrasound （CEUS）,and to analyze the correlation between quantitative parameters and microvascular density （MVD）. Methods A total of 19 patients with malignant colonic tumors underwent CEUS before operation. The enhancement appearance and the quantitative parameters were observed. The immunohistochemical detection was performed postoperatively to evaluate MVD. The correlation between quantitative parameters and MVD was analyzed. Results Different degrees of enhancement could be found in all patients,while hyper-enhancement was the main manifestation. The value of time to peak （TTP） in tumor tissues and the adjacent bowel wall was （24.4±6.4）s and （31.3±7.6）s respectively,while the absolute enhanced intensity was （11.5±2.9）dB and （6.1±2.3）dB,respectively. There was statistical difference of TTP and the absolute enhanced intensity between tumor tissues and the adjacent bowel wall （all P0.05）. The time-intensity curve showed quick-up and quick-down in 16 patients,while quick-up and slow-down model was found in 2 patients,and double-peak curve was found in 1 patient. MVD value of the lesions was （29.1±8.3） strips. MVD was positively correlated with peak intensity （PI） and the area under curve of arrival to peak time （AUC of ATP）（r=0.80,0.74,P0.01）. Conclusion CEUS can dynamically display the blood perfusion of malignant colonic tumors. PI and the AUC of ATP have good correlations with MVD,which is helpful to evaluate the angiogenesis of tumors before operation.
出处
《中国医学影像技术》
CSCD
北大核心
2010年第12期2317-2320,共4页
Chinese Journal of Medical Imaging Technology
关键词
结肠肿瘤
超声检查
微血管密度
时间-强度曲线
Colonic neoplasms
Ultrasonography
Microvascular density
Time-intensity curve
