摘要
目的胰性脑病(pancreatic encephalopathy,PE)是急性胰腺炎(acute pancreatit,AP)最危重并发症之一,死亡率高,较少见,应引起重视,文中探讨PE的临床特点、诊断、治疗、预后。方法总结17例AP并发PE临床资料进行分析。结果 17例PE中男女比例为10∶7,中年高发,重型占88.23%,胆源性占52.94%,精神神经兴奋型占47.06%,死亡率为52.94%。结论 PE大多数继发于重症胰腺炎(sereve acute pancreatitis,SAP),临床表现,辅助检查无特异性,需作排它诊断,治疗尚无特效,手术预后差,PE可能发病机制:胰酶对大脑损害是发生该病的病理基础,多因素是发病的诱因,抑制胰酶释放是预防此病发生的关键措施,维持正常的生理功能、控制感染、营养支持和补充维生素B1是预防Wernicke脑病发生的重要环节。
Objective Pancreatic encephalopathy is the most severe complication of acute pancreatitis with high mortality.It is less common and should be paid attention.This article discusses the clinical features of pancreatic encephalopathy and its diagnosis,treatment and prognosis.Methods The clinical data of 17 patients with acute pancreatitis complicated with pancreatic encephalopathy were analyzed.Results Among the 17 cases of pancreatic encephalopathy,the male to female ratio was 10∶7,the incidence in middle-aged was high,88.23% were severe,52.94% were biliary,mental-nerval excitated type accounted for 47.06% and the mortality rate was 52.94%.Conclusion Pancreatic encephalopathy secondary to severe acute pancreatitis is the majority of clinical manifestations,laboratory examinations show no specific marks,it subjects to exclusive diagnosis,there is no effective treatment,surgery has poor prognosis.Pathogenesis of pancreatic encephalopathy may be： Brain damage by pancreatic enzyme is the pathological basis of disease,multi-factors are the incentives.Inhibition of pancreatic enzyme release is a key measure of prevention;maintaining the normal physiological function,infection control,nutritional support and vitamin B1 supplement are important in prevention of Wernicke encephalopathy.
出处
《医学研究生学报》
CAS
2010年第11期1190-1191,共2页
Journal of Medical Postgraduates
关键词
急性胰腺炎
胰性脑病
发病机制
Acute pancreatitis
Pancreatic encephalopathy
Pathogenesis
