摘要
目的:研究银杏叶提取物对肾性高血压大鼠(RHR)的降压作用以及血清一氧化氮(NO)的影响,同时观察RHR心、脑、肾组织中丙二醛(MDA),超氧化物歧化酶(SOD)活性的变化。方法:采用两肾一夹法(2K1C)复制肾性高血压大鼠(RHR)模型,将造模成功的大鼠按照血压高低随机分为5组:空白对照组、银杏叶提取物高、中、低剂量组、阳性药卡托普利组,每组8只。在给药前和给药后2,4,6,8周测量大鼠的收缩压(SBP)和舒张压(DBP),在给药后8周,测量大鼠血清NO的含量,测心、脑、肾组织中MDA,SOD的变化。结果:给药8周后,银杏叶提取物明显降低RHR的血压,其中高剂量组的降压幅度与卡托普利组比较没有显著性差异;银杏叶提取物高剂量组和卡托普利组可以提高大鼠血清NO含量,提高心、脑、肾组织中SOD水平,降低MDA含量。结论:银杏叶提取物的降压作用可能与提高舒血管物质NO含量有关,并可能通过抗氧化起到保护靶器官的作用。
Objective：To study the effects of Ginkgo biloba extract on renal hypertension rats （RHR）. The serum nitric oxide （NO） content and the content of superoxide dismutase （SOD）, maleic disldehyde （MDA） in heart, brain and kidney tissue were investigated. Method：With the method of 2K1C, RHR were established and then the RHR were divided into five groups based on their blood pressure：blank group, model group, G. biloba extract high, middle, low dosage group and captopril group （n = 8, each）. Systolic blood pressure （SBP） and diastolic blood pressure（DBP） were measured respectively before therapy and two weeks, four weeks, six weeks, eight weeks after therapy. The serum content of NO and MDA,SOD in heart, brain and kidney were measured after eight weeks of therapy. Result： After eight weeks treatment, G. biloba extract significantly declined the pressure of RHR. captopril group and G. biloba extract high group had no significant difference. The two groups both increased the serum of NO and SOD in heart, brain and kidney, declined the MDA. Conclusion：The anti-hypertensive function of G. biloba extract may be related to NO, and protect target organ via antioxidation.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第18期146-149,共4页
Chinese Journal of Experimental Traditional Medical Formulae
