摘要
合成了１４种新的（Ｚ）［２（三芳基锡基）乙烯基］环戊醇类有机锡化合物，通过元素分析、ＩＲ、１ＨＮＭＲ对所合成的化合物进行了表征，结果表明（Ｚ）［２（三芳基锡基）乙烯基］环戊醇类有机锡化合物中乙烯式双键为顺式构型，分子内羟基与锡原子发生配位，形成五元螯合环．生物活性测定结果表明，二卤化物在抗癌，免疫及受体作用等方面具有优良的活性．
Fourteen 1(Z cyclopentanols were prepared by the reaction of triaryltin hydrids with 1ethynylcyclopentanol. The reaction of compounds 1 and 2 with ICI, Br2, and I2 gave six organotin halides, respectively. The compounds were characterized by elemental analysis, IR, 1H NMR and some of them showed antitumor and immune activities.
出处
《应用化学》
CAS
CSCD
北大核心
1999年第2期9-13,共5页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金
关键词
环戊醇
合成
生物活性
有机锡
triarylstannylvinyl cyclopentanol,synthesis,biological activity
