摘要
目的探讨尿激酶联合低分子肝素对肾病综合征并发下肢深静脉血栓的治疗作用。方法回顾性分析2002年3月至2009年12月在我院住院的42例肾病综合征并发下肢深静脉血栓形成的患者的临床资料，尿激酶联合低分子肝素治疗者27例，为A组，单纯普通肝素治疗者15例，为B组，比较2组疗效及不良反应。结果A组总有效率为88．9％，B组总有效率为53．3％，2组差异有统计学意义（P〈0．05）；2组出血发生率无差异（P〉0．05）；与B组相比，A组尿蛋白排泄量和血纤维蛋白原含量降低（P〈0．05）。结论尿激酶联合低分子肝素是肾病综合征并发下肢深静脉血栓的有效治疗方法之一，且出血发生率低。
Objective To study the therapeutic effects of urokinase combined with low molecular weight heparin （LMWH） for deep vein thrombosis （DVT） of lower limb in patients with nephritic syndrome （NS）. Methods A retrospective study was performed on 42 cases of DVT with NS from Mar. 2002 to Dec. 2009. They were divided into two groups： urokinase combined with LMWH group （group A, n = 27） and heparin group （group B, n = 15）. The efficacy and side effects of two groups were evaluated. Results The total effective rate in group A and group B was 88.9% and 53.3% respectively with the difference being significant （P〈0. 05）. There was no statistically significant difference in hemorrhagic complications between two groups （P〈0. 05）. As compared with group B, urinary albumin excretion and blood fibrinogen in group A were obviously decreased （P〈0. 05）. Conclusion Urokinase combined with LMWH is one of effective methods for treating DVT with NS.
出处
《临床肾脏病杂志》
2010年第11期500-503,共4页
Journal Of Clinical Nephrology
关键词
肾病综合征
深静脉血栓
尿激酶
肝素
低分子量
Nephritic syndrome
Deep vein thrombosis
Urokinase
Heparin, low molecular weight
