摘要
目的观察依达拉奉治疗急性大面积脑梗死的疗效及其作用机制。方法 62例急性大面积脑梗死患者随机分为依达拉奉组和对照组。在脑梗死常规治疗基础上,依达拉奉组给予依达拉奉30mg静脉滴注,每天2次,连用2周。观察治疗前后两组神经功能缺损程度评分(NDS)、日常生活能力量表Barthel指数(BI)、血清超氧化物歧化酶(SOD)、脂质过氧化物(LPO)检测,比较两组的疗效。结果两组治疗后NDS比治疗前均有明显降低(均P<0.01),BI指数升高,血清SOD活性升高,LPO含量下降;与治疗前相比,差异有统计学意义(均P<0.01)。与对照组相比,依达拉奉组的变化更显著(均P<0.01);依达拉奉组的总有效率(87.5%)显著高于对照组(66.6%)(P<0.01)。结论依达拉奉具有明显清除自由基的作用,治疗急性大面积脑梗死有肯定的疗效。
Objective To investigate the efficacy and mechanism of Edaravone for treatment on acute massive cerebral infarction.Methods Totally 62 patients with acute massive cerebral infarc-tion were randomly divided into Edaravone group（32 cases） and control group（30 cases）;and were treated with conventional therapy.Edaravone group patients were admitted with Edaravone 30 mg,twice a dayt,wo weeks.Neurologic function deficit scores（NDS）,Barthel index（BI） a,ctivity of super-oxide dismutase（SOD） l,ipid peroxide（LPO） were detected pre and post treatment.The efficacy was compared between the two grups.Results The NDS of two groups were significantly lower than those before treatment,BI was increasedt,he level of serum SOD was increasedt,he levels of serum LPO was decreased in the two groups.Compared with those pre treatmentt,he changes of all the targets were sig-nificantly different（all P 〈0.01） a,nd Edaravone group improvement were obviously better than control group（all P 〈0.01）.The total effective rate in Edaravone group（87.5%） was significantly higher than that in control group（66.6%）（P 〈0.01）.Conclusion Treatment with Edaravone for acute massive cerebral infarction is effectual.
出处
《医药论坛杂志》
2010年第20期69-71,共3页
Journal of Medical Forum
关键词
急性大面积脑梗死
依达拉奉
疗效
Acute massive cerebral infarction
Edaravone
Efficacy
