摘要
目的:探讨氯氮平的使用剂量与癫痫发作的影响关系。方法:回顾性调查1988年1月至1995年12月使用氯氮平治疗的1303例住院病例,采用自制《氯氮平临床使用调查表》逐一登记,所得数据处理由微机完成。结果:氯氮平引起癫痫发作总的发生率为11.5％,若将日剂量大小分高、中、低三组,其发生率依次为25.97％、6.46％、9.05％。其中高剂量的单用药和多药联用的发生平差别极显著(X^2=7.1405,P<0.01),而低、中剂量二组之间则无统计学上的差异。结论:氯氮平所致的癫痫发作可能与用药剂量、多药联用、调整药量过快等因素有关。
To find the relationship between the dosage of clozapine and epilepsy attack, 1 303 patients who were given clozapine between Dec. 1995 and Jan. 1988 were retrospectively investigated. Self-developed questionnaires were used for data collection and data were subjected to computer-aided processing. Our study showed that the total incidence was 11.5‰ The incidences for high, medium and low dosage groups were 25.97‰, 6.46‰,9.05‰ respectively. The difference in incidence between the high-dosage single drug group and multi-drug group was very significant (x2=7.140 5, P<0.01) while there was no significant difference in incidence between low-dosage and high-dosage groups. It is concluded that clozapine-in-duced epilepsy attack may be associated with dosage, combination use of multi-drugs and dosage change with short time.
出处
《药物流行病学杂志》
CAS
1999年第2期82-83,共2页
Chinese Journal of Pharmacoepidemiology
关键词
氯氮平
癫痫
药物不良反应
Clozapine
Epilepsy attack
Adverse drug reaction
