摘要
目的比较西酞普兰与文拉法辛治疗精神分裂症后抑郁症状的疗效和安全性。方法 50例精神分裂症后抑郁患者随机分为2组,分别用西酞普兰和文拉法辛治疗6周。采用汉密尔顿抑郁量表(HAMD),简明精神病量表(BPRS)和副反应评定量表(TESS)于治疗前和治疗1、2、4、6周末分别评定疗效和不良反应。结果 2组治疗后HAMD和BPRS评分均较治疗前下降(P<0.01),2组疗效无显著性差异(P>0.05),2组不良反应发生率无显著性差异(P>0.05)。结论西酞普兰与文拉法辛治疗精神分裂症后抑郁疗效相当,安全性高,不良反应轻微。
Objective To explore the efficacy and safety of citalopram and venlafaxine in the treatment of post-schizophrenia depression symptoms. Methods Fifty patients with post-schizophrenia depression were randomly treated with citalopram or venlafaxine for 6 weeks, and measured with Hamilton depressive scale （HAMD）, brief psychiatric rating scale （BPRS） and treatment emergent symptom scale （TESS） before treatment and lst,2nd,4th,6th weekend after treatment. Results The total scores of HAMD and BPRS of two groups were significantly lower after treatment（P〈0.05）, adverse events of two groups had no significant difference. The side-effects showed no significant difference between the two groups （P〉0. 05）. Conclusion The effect of citalopram and venlafaxine in the treatment of post-schizophrenia depression is fairly and safe,and with mild adverse reactions.
出处
《中国实用神经疾病杂志》
2010年第24期34-36,共3页
Chinese Journal of Practical Nervous Diseases
