摘要
本文报道了液相法合成促甲状腺素释放激素(TRH)的改进方法,Z-pGlu-ONB与His-OK反应得到z-pGlu-His-OH结晶,此结晶在HONB/DCC存在下与His-Pro-NH_2偶合得Z-pGlu-His-Pro-NH_2晶体。所得保护三肽然后在Pd/c催化下常压氢化除去保护基即得纯的TRH,不必进一步纯化即可供生化和化学研究用,产率高。
TRH was synthesized by a new method introduced by G. Hotanaka in 1974. According to this principle of this method, we have made each step concrete and obtained a good result. This method is easy to undertake and not necessary to make chromatography for purification.
关键词
促甲状腺素
释放激素
合成
thyrotrop in releasing hormone
TRH
peptide Synthesis
