摘要
监测围产儿7712例,发现先天畸形儿67例,占8.68‰。同期围产儿死亡148例,围产儿死亡率19.19‰。125例作尸检,尸检率84.46％。148例死亡围产儿中先天畸形29例,占195.94‰,在围产儿死因中占第2位。7564例活产儿中发现畸形38例,占5.02‰。畸形以神经系统畸形、心脏缺陷,呼吸器官发育畸形等为多见,平均每例含2.09畸形次。指出加强孕期自身防护、加强产前监护、染色体检查、B型超声波检查及血清α-FP测定,可降低出生缺陷发生率。
7712 cases of perinatal fetuses and newborns from 1986~1988 were analysed. 67 them were found to have congenital malformations. The birth defect rate was 8.68‰. During this period 148 cases were perinatal deaths. The perinatal mortality rate was 19.19‰. Autopsy was performed in 125 cases and the autopsy rate was 84.46%. Twenty-nine of 148 cases of perinatal death were diagnosed as congenital malformation. Malformation took second place in the causes of perinatal death,38 (5.02‰) live-born babies with malformations were found, The malformation appeared to be NTD, congenital heart disease, and hypoplasia of the respartory organs ect. Based on our studies, we consider that it is important to avoid expesure to teratogenic factors during early pregnancy. Chromosome aralysis, 'B' ultrasonography and α-FP test are the screening methods that can be used to decrease the incidence of fetal malformation.
关键词
出生缺陷
围产儿
先天畸形
perinatal period
birth defect
congenital malformation
