摘要
目的分析金黄色葡萄球菌的临床分布及耐药现状,为临床抗感染治疗提供理论依据。方法 API系统鉴定细菌,采用纸片扩散法对金黄色葡萄球菌进行药敏试验,用头孢西丁纸片扩散法筛选耐甲氧西林金黄色葡萄球菌(MRSA)。结果共检出金黄色葡萄球菌317株,其中MRSA有178株,甲氧西林敏感金黄色葡萄球菌(MSSA)139株。除青霉素、红霉素及克林霉素外,MSSA对其它抗生素均有较好的敏感性,而MRSA除对万古霉素、利奈唑胺、替考拉宁、呋喃妥因、氯霉素及复方新诺明敏感外,对其它抗生素均耐药。没有发现对万古霉素及利奈唑胺耐药的菌株。结论 MRSA多重耐药,应加强对其耐药率监测,有效地预防及控制其感染。
【Objective】 To study the clinical distribution and drug resistance of Staphylococcus aureus in order to guide the proper use of antibiotics in clinic.【Methods】 Bacterial isolates were identified by API system,the susceptibility of antibiotics was performed by Kirby-Bauer method,and Kirby-Bauer method of cefoxitin was used to select meticillin-resistant Staphylococcus aureus（MRSA）.【Results】 Of 317 strains of isolated Staphylococcus aureus,178 strains were MRSA and 139 strains were meticillin-sensitive Staphylococcus aureus（MSSA）.Except for penicillin,erythromycin and clindamycin,MSSA were sensitive to the other antibiotics.while MRSA were only sensitive to vancomycin,linezolid,teicoplanin,nitrofurantoin,chloramphenicol and trimethoprim/sulfamethoxazolen,and were resistant to all other antibiotics.No strain which was resistant to vancomycin and linezolid was isolated.【Conclusion】MRSA are multidrug resistant,the drug resistance of MRSA should be monitored closely so as to effectively prevent and control its infection.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第6期897-899,共3页
China Journal of Modern Medicine
