摘要
介于组织与血液之间的内皮细胞具有多种功能，在保护血管完整性和维持血液流动性方面起到关键性作用[1,2]。自本世纪80年代，人们才认识到纤维蛋白原、其它凝血因子、纤维蛋白形成与溶解等都参与动脉粥样硬化的发生发展[3]。现今内皮细胞损伤在动脉粥样硬化发生发展中的重...
Since the 1980s, the mechanism of endothelial involvement in the occurrence and development of atherosclerosis has been extensively studied. The research in the recent years suggests that abnormal coagulation and fibrinolysis following endothelial dysfunction are closely relaied to atherosclerosis.Quiescent endothelium normally maintains an anticoagulant surface. But the abnormal cells have coagulative ability, which can activate the factor of coagulation and promote the aggregation of the platelet, and inhibit normal modulation of coagulating mechanism and fibrinolysis. The activation of coagulation and the inhibition of fibrinolysis not only enhance atherosclerosis but also promote the depositing of fibrinogen in the periadvential matrix of the vessels. This benefits the stabilizing of atherosclerosic plaque. The impairment of the endothelium often occurs in the early stage of atherosclerosis, so the evaluation of the endothelial function contributes to the early diagnosis of atherosclerosis. Now there are several methods to evaluate the endothelial function. A role of the endothelial cells in cardiovascular disease might be dependent on these phenotypic alterations, rather than on actual damage itself. The endothelial dysfunction is reversible within days, months, or years and this reversibility appears to show individual variation. This provides a valuable hint for the treatment and prevention of atherosclerosis.
出处
《基础医学与临床》
CSCD
1999年第3期24-27,32,共5页
Basic and Clinical Medicine
