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恩氟沙星的合成 被引量：2

SYNTHESIS OF ENROFLOXACIN
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摘要 改进了喹诺酮酸类抗菌药恩氟沙星及其中间体乙基哌嗪的合成工艺，使其更适合于工业生产。 Enrofloxacin as a new antibacterial drug was synthesized from 1 cyclopropy1 6 fluoro 7 chloro 1,4 dihydro 4 oxo 3 quinolinecarboxylic acid and excess ethylpiperazine.The overall yield was 79.6%.\;
作者 程国侯 汤文军 张玉华
机构地区 华东理工大学药物化学研究室
出处 《中国医药工业杂志》 CAS CSCD 北大核心 1999年第7期291-292,共2页 Chinese Journal of Pharmaceuticals
关键词 恩氟沙星 乙基哌嗪 合成 抗菌药 enrofloxacin, ethylpiperazine, synthesis
分类号 TQ463.5 [化学工程—制药化工]
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同被引文献21

  • 1林原斌,陈弘,申东升.硫酸二乙酯法合成N-乙基间甲苯胺——芳胺N-烷基化研究(Ⅳ)[J].湘潭大学自然科学学报,1993,15(2):91-93. 被引量：1
  • 2夏明珠,王风云,杨廷海,雷武.1-乙基-4-氧-7-甲基-1,8-萘啶-3-羧酸的合成[J].应用化学,2007,24(4):461-464. 被引量：1
  • 3Cinquina A L, Roberti P, Giannetti L, et al. Determination of enrofloxacin and its metabolite ciprofloxacin in goat milk by high- performance liquid chromatography with diodearray detection: optimization and validation [ J ]. Journal of Chromatography A, 2003,987 ( 1/2 ) :221 - 226.
  • 4Olutosin R Idowu ,James O Peggins. Simple, rapid determination of enrofloxacin and ciprofloxacin in bovine milk and plasma by high- performance liquid chromatography with fluorescence detection [ J ]. Journal of Pharmaceutical and Biomedical Analysis,2004,35 (1) :143 -153.
  • 5Julie Sunderland, Andrew M Lovering, Caroline M Tobin, et al. A reverse-phase HPLC assay for the simuhaneous determination of enrofloxacin and ciprofloxacin in pig faeces [ J ]. International Journal of Antimicrobial Agents, 2004,23 ( 4 ) : 390 - 393.
  • 6Alaa S Amin, Hassan A Dessouki, Ibrahim A Agwa. Ionpairing and reversed phase liquid chromatography for the determination of three different quinolones : Enrofloxaein, lomefloxacin and ofloxacin [ J ]. Arabian Journal of Chemistry, In Press, Accepted Manuscript, Available online 25 June,2010.
  • 7Barr6n D, Jim:nez-Lozano E, Cano J, et al. Determination of residues of enrofioxacin and its metabolite ciprofloxacin in biological materials by capillary electrophoresis [ J ]. Journal of Chromatography B: Biomedical Sciences and Applications, 2001, 759(1) :73 -79.
  • 8Zhou X M, Xing D, Zhu D B, et al. Development and application of a capillary electrophoresis electrochemiluminescent method for the analysis of enrofloxacin and its metabolite ciprofloxacin in milk [ J ]. Talanta,2008,75 ( 5 ) : 1300 - 1306.
  • 9Mostafa S, E1-Sadek M, Esmail Awad A11a. Spectrophotometric determination of enrofioxacin and pefloxacin through ion-pair complex formation [ J ]. Journal of Pharmaceutical and Biomedical Analysis ,2002,28 ( 1 ) : 173 - 180.
  • 10Mostafa S, E1-Sadek M, Esmail Awad Alia. Spectrophotometric determination of ciprofloxaein, enrofloxacin and pefloxacin through charge transfer complex formation [ J ]. Journal of Pharmaceutical and Biomedical Analysis ,2002,27 (1/2) : 133 - 142.

引证文献2

二级引证文献3

中国医药工业杂志
1999年 第7期

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