摘要
目的:探讨小剂量每日服用他达那非对改善勃起功能障碍(ED)患者内皮舒张功能及勃起硬度的作用。方法:通过国际勃起功能问卷评分-5(IIEF-5)、勃起硬度分级评分(EHGS)以及肱动脉血流介导的舒张反应(FMD)等方法对24例勃起功能正常者及60例ED患者口服5mg/d他达那非6～8周治疗前后进行评估。结果:51例ED患者完成治疗及随访。与对照组相比,ED患者IIEF-5、EHGS以及FMD明显降低(P均<0.01)。他达那非治疗ED的有效率为96.1%(49/51),治疗后较治疗前IIEF-5、EHGS以及FMD明显改善(P均<0.01)。结论:长期小剂量服用他达那非可明显改善ED患者的血管内皮功能及勃起硬度。
Objective：To evaluate the effects of daily medication of low-dose tadalafil on the improvement of endothelial function and erectile hardness in erectile dysfunction（ED）patients.Methods：A total of 60 ED patients and 24 controls were treated with oral tadalafil at 5 mg/d for 6-8 weeks,and evaluated by international index of erectile function-5（IIEF-5）,erectile hardness grading scale（EHGS）and brachial artery flow-mediated dilation（FMD）test before and after the treatment.All the data obtained were analyzed by independent-sample and paired-sample t tests,respectively.Results：The treatment and follow-up were accomplished in 51 of the ED cases.Compared with the controls,the ED patients showed significantly lower scores on IIEF-5（23.6±1.0 vs 10.3±4.5,P0.01）,EHGS（3.7±0.5 vs 2.0±0.6,P0.01）and FMD（14.1±2.1 vs 8.1±1.1,P0.01）.Daily medication of tadalafil achieved an effectiveness rate of 96.1%（49/51）in the treatment of the ED patients,and significantly improved their scores on IIEF-5（16.9±3.9 vs 10.6±4.5,P0.01）,EHGS（2.6±0.7 vs 2.0±0.6,P0.01）and FMD（9.2±1.7 vs 8.1±0.9,P0.01）,as compared with pretreatment.Conclusion：Long-term daily medication of low-dose tadalafil can significantly improve endothelial function and erectile hardness of ED patients.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2010年第11期1052-1055,共4页
National Journal of Andrology
