摘要
目的:研究骨巨细胞瘤中Skp2的表达并探讨其与放射学分期、肿瘤复发及病理分级等的关系。方法:运用免疫组织化学SP法检测44例骨巨细胞瘤中Skp2的表达情况。结果:Skp2的阳性表达率为65.91%,在影像学分期1型、2型、3型中阳性率分别为50%、64.29%、100%(P<0.05)。Skp2在复发组与未复发组的阳性表达率分别为91.67%(11/12)、56.25%(18/32)(P<0.05)。Skp2、骨皮质破坏或软组织浸润以及手术方式对复发均有明显影响,其中前两者是骨巨细胞瘤复发的危险因素,截骨的手术方式则是骨巨细胞瘤复发的保护因素。结论:Skp2阳性表达与骨巨细胞瘤的复发有关,在骨巨细胞瘤细胞的增殖过程中可能起重要作用。检测Skp2可能作为骨巨细胞瘤侵袭状态、复发倾向的判定以及手术治疗方式选择的一种参考指标。
Objective：To study the expression of Skp2 protein in giant cell tumor of bone（GCT） and the correlation between their expression and radiological stage,tumor recurrence,pathological stage.Methods：Immunohistochemical SP staining method was used to detect the expression of Skp2 in 44 cases of GCT.Results：The positive rate of Skp2 was 65.91%.According to radiological stage（stage 1,2 and 3）,the positive rates of Skp2 were 50%,64.29%,100%（P 0.05）,respectively.The positive rate of Skp2 in recurrent cases was 91.67% higher than 56.25% in cases without recurrence（P 0.05）.The positive rates of Skp2,destruction of bony cortex or infiltration of parenchyma and operation modality had influence on recurrence of GCT.The first two were risk factors of recurrence of GCT.The complete ectomy was protective factor of GCT.Conclusion：The positive expression of Skp2 is associated with recurrence of GCT and the development and progression of GCT.Skp2 may be regarded as one of valuable indexes of infiltrated state,decision of tendency to recur and selection of operation modality.
出处
《现代肿瘤医学》
CAS
2010年第12期2456-2458,共3页
Journal of Modern Oncology
基金
江苏省昆山市2010年度科研基金(编号:昆科KS1004)
