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CT灌注参数变化在肺癌放疗中的应用 被引量:3

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摘要 目的:观察肺癌患者放疗前后CT灌注参数的变化,监测治疗疗效,评价预后。方法:对诊断肺癌的24例患者放疗前行CT灌注扫描。非离子型对比剂50ml,注射速率4.0ml/s,延迟10s,扫描时间50s。放疗后再次进行CT灌注扫描。比较治疗前后灌注参数的变化及其与无进展生存时间和总生存时间的关系。结果:24例患者中,早期疗效评价为缓解者14例,未缓解者10例。表面通透性(PS)值升高者13例,治疗前为(13.7±6.2)ml·min-1·100g-1,治疗后为(20.1±7.5)ml·min-1·100g-1,差异有统计学意义(P=0.013);PS值降低者11例,治疗前为(15.3±5.1)ml·min-1·100g-1,治疗后为(8.2±5.5)ml·min-1·100g-1,差异有统计学意义(P=0.000)。升高组和降低组的中位无进展生存时间分别为4.2个月和19.0个月(P=0.000),中位总生存时间分别为7.9个月和19.3个月,差异有统计学意义(P=0.002)。结论:肺癌患者放疗前后,CT灌注值的变化对预后评估有一定作用,升高者预后不良。
出处 《现代肿瘤医学》 CAS 2010年第12期2406-2408,共3页 Journal of Modern Oncology
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