摘要
目的:探讨Podoplanin及CD34在口腔颌面部脉管畸形诊断中的意义。方法:收集30例病理诊断为脉管畸形的标本,进行HE染色,采用免疫组织化学方法观察Podoplanin和CD34的表达。结果:Podoplanin和CD34双重染色结果显示,淋巴管对Podoplanin有较好的阳性表达,呈现深褐色;而毛细血管对CD34有较好的阳性表达,呈现蓝色。结论:Podoplanin和CD34双重染色,在畸形血管和淋巴管中有较好的表达,能够辨别脉管畸形中的毛细淋巴管和毛细血管,可以作为组织学诊断的辅助。
Objective：To discuss the significance of Podoplanin and CD34in the diagnosis of oral vascular malformation.Methods：Eighteen specimens with oral vascular malformation were studied with HE stain,Podoplanin stain,and CD34 stain respectively.Results：After Podoplanin and CD34double staining,Podoplanin was positively expressed in lymphatic vessels and stained puce,while CD34 was positively expressed in capillary vessels and stained blue.Conclusion：It is easier to distinguish capillary vessel,and capillary lymphatic vessel when use double stains technique of Podoplanin and CD34.Podoplanin and CD34 gain well expression in malformation capillary lymphatic vessel and capillary vessel and the Podoplanin-CD34 double stains technique can be used to enhance the veracity of pathological diagnosis.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2010年第6期804-806,860,共4页
Medical Journal of Wuhan University
基金
湖北省卫生厅资助项目(编号:JX3B25)
湖北省自然科学基金资助项目(编号:2006ABA249)
