摘要
CD4+T细胞按照分化及功能特征分为Th1、Th2、Th17和Treg4个主要的功能性亚群,各亚群间的免疫平衡紊乱与疾病的发生和发展相关。炎症性肠病是由遗传、环境、免疫等多因素参与的肠道慢性炎症性疾病,近年研究表明CD4+T细胞亚群之间的免疫失衡可能是其发病的最直接和最重要的因素,本文就该领域的新进展作一综述。
CD4＋ T cell can be mainly divided into four subsets according to distinct differentiation and function characters,termed Th1,Th2,Th17 and Treg. When aberrant,these different subsets will be responsible for disease status. Inflammatory bowel disease （ IBD） is a chronic inflammatory disease caused by multiple factors,including genetics,environment and immunology. Recent evidences suggested that the balance of CD4 ＋ T cell subsets played an important role in IBD. The present article will be reviewed the latest studies in this field.
出处
《胃肠病学和肝病学杂志》
CAS
2010年第11期1058-1061,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
广东省科技计划项目(2009B03081174)
关键词
CD4+T细胞
炎症性肠病
免疫
CD4＋ T cell
Inflammatory bowel disease
Immunology
