摘要
目的探讨钙卫蛋白监测在炎症性肠病中的意义。方法选取炎症性肠病患者20例和健康对照者20例,采用ELISA方法测定粪便中钙卫蛋白的含量,与C反应蛋白(CRP)进行比较。结果炎症性肠病活动组粪便钙卫蛋白含量高于正常对照组,差异有统计学意义(P<0.05)。炎症性肠病活动组中激素组和非激素组钙卫蛋白含量均高于对照组和缓解组。活动期组中激素组CRP降低与对照组和缓解组比较无明显差异,而活动期组中非激素组CRP继续维持较高水平,高于对照组和缓解期组,差异均有统计学意义(P<0.01)。结论粪便中的钙卫蛋白在作为监测炎症性肠病患者的活动性及黏膜损伤的临床指标方面具有重要的意义。
Objective To investigate the clinical value of fecal calprotectin during the clinical course of inflammatory bowel disease. Methods ELISA assay was used to measure the concentrations of calprotectin in feces from 20 IBD patients and 20 healthy controls. Serological parameter C-creative protein （ CRP） was compared. Results Fecal calprotectin of the IBD patients was higher than that in the control group （ P 0. 01） . Fecal calprotectin of the IBD patients in activity group with and without glucocorticosteroid both was higher than that in the control group and the remission group. In the meanwhile,CRP of the IBD patients in activity group managemented with glucocorticosteroid was similar to the remission and control groups. On the other hand,CRP of the IBD patients in activity group managemented without glucocorticosteroid was kept in the high level,and higher than that in the remission and control groups（ P 0. 01） . Conclusion Fecal calprotectin has important value to monitor the disease activity and mucous damage.
出处
《胃肠病学和肝病学杂志》
CAS
2010年第11期1043-1044,共2页
Chinese Journal of Gastroenterology and Hepatology
关键词
钙卫蛋白
炎症性肠病
黏膜损伤
Fecal calprotectin
Inflammatory bowel disease
Mucosa injury
