摘要
目的观察奥沙利铂联合卡培他滨(XELOX)双周方案治疗晚期胃、结直肠癌的临床疗效和不良反应。方法 46例晚期胃、结直肠癌患者应用奥沙利铂85mg/m2,静滴2h,d1;卡培他滨(900～1000)mg/m2,一日分两次,口服,d1～10;14d为1周期,4周期评价疗效。结果 46例均可评价疗效,CR4例,PR24例,RR65.2%;不良反应主要为I～Ⅱ度血液学毒性,恶心、呕吐,末梢神经异常及手足综合征。结论奥沙利铂联合卡培他滨(XELOX)双周方案治疗晚期胃、结直肠癌疗效确切,耐受性好,值得临床推广应用。
Objective To assess the efficacy and tolerability of oxaliplatin combination capecitabine（XELOX） biweekly in patients with advanced gastrointestinal cancer.Methods 46patients with advanced gastrointestinal cancer were treated with oxaliplatin 80mg/m^2 ivgtt d1 in 2 hours and capecitabine（XELOX） 900～1000mg/m^2 bid,po d1～10.14 days was one cycle.The effect was evaluated after four cycles.Results All cases were evaluated,4 cases were complete response and 24 cases were partial response.The overall response rate was 65.2%.The main adverse effects were gradeⅠ-Ⅱhematological toxicity,nausea and vomit,peripheral neuropathy and hand-foot syndrome.Conclusion The combination of capecitabine and oxaliplatin（XELOX）is an effective and better tolerated treatment in advanced gastrointestinal cancer and can yield promising clinical application.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2010年第11期1306-1307,共2页
Cancer Research on Prevention and Treatment
关键词
奥沙利铂
卡培他滨
联合化疗
晚期胃癌
晚期结肠癌
Oxaliplatin
Capecitabine
Combination chemotherapy
Advanced carcinoma of stomach
Advanced colon cancer
